ArticleScience advances2023
Retinal waves align the concentric orientation map in mouse superior colliculus to the center of vision.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Distinct cortical spatial representations learned along disparate visual pathways.Science advances · 2026Article
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Retinal origin of orientation but not direction selective maps in the superior colliculus.Current biology : CB · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Neurons in the mouse superior colliculus (SC) are arranged in a concentric orientation map, which is aligned to the center of vision and the optic flow experienced by the mouse. The origin of this map remains unclear. Here, we propose that spontaneous retinal waves during development provide a scaffold to establish the concentric orientation map within the SC and its alignment to the optic flow. We test this hypothesis by modeling the orientation-tuned SC neurons that receive ON/OFF retinal inputs. Our model suggests that the propagation direction bias of stage III retinal waves, together with OFF-delayed responses, shapes the spatial organization of the orientation map. The OFF delay establishes orientation-tuned neurons by segregating their ON/OFF receptive subfields, the wave-like activities form the concentric pattern, and the direction biases align the map to the center of vision. Together, retinal waves may play an instructive role in establishing functional properties of single SC neurons and their spatial organization within maps.
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