ArticlePLoS computational biology2023
Pupillary response is associated with the reset and switching of functional brain networks during salience processing.
Article in PLoS computational biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- Exploration vs. Exploitation in a Novel Complex Card Matching Task: Evidence from Pupillometry.Cognitive, affective & behavioral neuroscience · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Investigating the test-retest reliability and behavioral correlates of pupil responses in the n-back task.Scientific reports · 2026Article
- An EEG dataset with carbon wire loops in cognitive tasks and resting state inside and outside MR scanners.Scientific data · 2026Article
- Effect of database, pre-processing pipeline, and scan duration on rs-fMRI functional connectivity based treatment targets for TMS obtained using the Stanford Neuromodulation Therapy (SNT) protocol.Psychoradiology · 2026Article
- Brain-Pupil Coupling Revealed Through Deep Learning of Intracranial Recordings.Human brain mapping · 2025Article
- Unveiling the dynamic effects of major depressive disorder and its rTMS interventions through energy landscape analysis.Frontiers in neuroscience · 2025Article
- Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex.Scientific reports · 2024Article
- Pupil dilation and behavior as complementary measures of fear response in Mice.Cognitive neurodynamics · 2024Article
- Identifying the bioimaging features of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice.Nature communications · 2024Article
- An fMRI examination of the role of the Locus Coeruleus in state regulation in ADHD.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interface between processing internal goals and salient events in the environment involves various top-down processes. Previous studies have identified multiple brain areas for salience processing, including the salience network (SN), dorsal attention network, and the locus coeruleus-norepinephrine (LC-NE) system. However, interactions among these systems in salience processing remain unclear. Here, we simultaneously recorded pupillometry, EEG, and fMRI during an auditory oddball paradigm. The analyses of EEG and fMRI data uncovered spatiotemporally organized target-associated neural correlates. By modeling the target-modulated effective connectivity, we found that the target-evoked pupillary response is associated with the network directional couplings from late to early subsystems in the trial, as well as the network switching initiated by the SN. These findings indicate that the SN might cooperate with the pupil-indexed LC-NE system in the reset and switching of cortical networks, and shed light on their implications in various cognitive processes and neurological diseases.
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