ArticlePLoS pathogens2023
A secreted protease-like protein in Zymoseptoria tritici is responsible for avirulence on Stb9 resistance gene in wheat.
Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Impact of Drought on Cereals Infected withPathogens (Basel, Switzerland) · 2026Review
- Genome-host association mapping reveals wheat pathogen genes involved in host specialization.Nature plants · 2026Article
- EffectorFisher: association of disease phenotype with pangenomic protein-isoform profiles for improved prediction of fungal pathogenicity effectors.Scientific reports · 2026Article
- Evolutionary History and Diversification of M35 Metalloproteases in Dothideomycetes: A Phylogenomic Overview and Case Study in Corynespora cassiicola.Current microbiology · 2026Article
- Integrating host-pathogen interaction genomics to boost wheat defense against septoria tritici blotch.BMC genomics · 2025Article
- Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen.Nature communications · 2025Article
- Turning Susceptibility into Strength: A New Era of Durable Resistance in Plants Through Genome Editing.Plants (Basel, Switzerland) · 2025Review
- Population genomics and molecular epidemiology of wheat powdery mildew in Europe.PLoS biology · 2025Article
- Septoria tritici blotch resistance gene Stb15 encodes a lectin receptor-like kinase.Nature plants · 2025Article
- Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici.PLoS pathogens · 2025Article
- Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein.PLoS pathogens · 2024Article
- An array of Zymoseptoria tritici effectors suppress plant immune responses.Molecular plant pathology · 2024Article
- Stomatal penetration: the cornerstone of plant resistance to the fungal pathogen Zymoseptoria tritici.BMC plant biology · 2024Article
- First Insight into the Degradome ofInternational journal of molecular sciences · 2024Article
- Defense Pathways of Wheat Plants Inoculated withLife (Basel, Switzerland) · 2024Review
- Quantitative pathogenicity and host adaptation in a fungal plant pathogen revealed by whole-genome sequencing.Nature communications · 2024Article
- Sas3-mediated histone acetylation regulates effector gene activation in a fungal plant pathogen.mBio · 2023Article
- Genome engineering of disease susceptibility genes for enhancing resistance in plants.Functional & integrative genomics · 2023Review
- Quantitative and qualitative plant-pathogen interactions call upon similar pathogenicity genes with a spectrum of effects.Frontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zymoseptoria tritici is the fungal pathogen responsible for Septoria tritici blotch on wheat. Disease outcome in this pathosystem is partly determined by isolate-specific resistance, where wheat resistance genes recognize specific fungal factors triggering an immune response. Despite the large number of known wheat resistance genes, fungal molecular determinants involved in such cultivar-specific resistance remain largely unknown. We identified the avirulence factor AvrStb9 using association mapping and functional validation approaches. Pathotyping AvrStb9 transgenic strains on Stb9 cultivars, near isogenic lines and wheat mapping populations, showed that AvrStb9 interacts with Stb9 resistance gene, triggering an immune response. AvrStb9 encodes an unusually large avirulence gene with a predicted secretion signal and a protease domain. It belongs to a S41 protease family conserved across different filamentous fungi in the Ascomycota class and may constitute a core effector. AvrStb9 is also conserved among a global Z. tritici population and carries multiple amino acid substitutions caused by strong positive diversifying selection. These results demonstrate the contribution of an 'atypical' conserved effector protein to fungal avirulence and the role of sequence diversification in the escape of host recognition, adding to our understanding of host-pathogen interactions and the evolutionary processes underlying pathogen adaptation.
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