ArticleCell reports2023
Low-dimensional organization of global brain states of reduced consciousness.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Behavioral contagion leads the brain functional network towards a more balanced state.Brain imaging and behavior · 2026Article
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- A mechanism for the emergence of low-dimensional structures in brain dynamics.NPJ systems biology and applications · 2025Article
- Modelling low-dimensional interacting brain networks reveals organising principle in human cognition.Network neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness.Frontiers in neuroscience · 2025Article
- Deep learning models reveal the link between dynamic brain connectivity patterns and states of consciousness.Scientific reports · 2024Article
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.PLoS computational biology · 2024Article
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- Deciphering network dysregulations and temporo-spatial dynamics in disorders of consciousness: insights from minimum spanning tree analysis.Frontiers in psychology · 2024Article
- Inducing a meditative state by artificial perturbations: A mechanistic understanding of brain dynamics underlying meditation.Network neuroscience (Cambridge, Mass.) · 2024Article
- Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex.PLoS computational biology · 2024Article
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 11 countries.
Funding
Abstract
Brain states are frequently represented using a unidimensional scale measuring the richness of subjective experience (level of consciousness). This description assumes a mapping between the high-dimensional space of whole-brain configurations and the trajectories of brain states associated with changes in consciousness, yet this mapping and its properties remain unclear. We combine whole-brain modeling, data augmentation, and deep learning for dimensionality reduction to determine a mapping representing states of consciousness in a low-dimensional space, where distances parallel similarities between states. An orderly trajectory from wakefulness to patients with brain injury is revealed in a latent space whose coordinates represent metrics related to functional modularity and structure-function coupling, increasing alongside loss of consciousness. Finally, we investigate the effects of model perturbations, providing geometrical interpretation for the stability and reversibility of states. We conclude that conscious awareness depends on functional patterns encoded as a low-dimensional trajectory within the vast space of brain configurations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.