ArticleInterdisciplinary cardiovascular and thoracic surgery2023
Indocyanine green inhalation visualizes lung tumour during video-assisted thoracoscopic surgery.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Intraoperative Molecular Imaging in Thoracic Oncology: Expanding the Observable Disease Space.Cancers · 2026Review
- Intraoperative Nodule Localization in Non-Small-Cell Lung Cancer: Existing and Emerging Techniques.Cancers · 2026Review
- Feasibility and Safety of CIOS Spin for One-Stop Pulmonary Nodule Localization and Resection.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Indocyanine green combined with autologous blood and methylene blue for pulmonary nodules localization in 272 cases: a novel localization method.Updates in surgery · 2026Article
- Evaluation of indocyanine green inhalation to detect air leak sites during video-assisted thoracoscopic surgery: a prospective study.BMC surgery · 2025Article
- Indocyanine green nebulization visualizes the pulmonary bronchus during video-assisted thoracoscopic surgery.Journal of cardiothoracic surgery · 2025Article
- Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study.Respiratory research · 2024Article
- A Green Lantern for the Surgeon: A Review on the Use of Indocyanine Green (ICG) in Minimally Invasive Surgery.Journal of clinical medicine · 2024Review
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Authors and funding
10 authors.
Funding
Abstract
objectivesAccurate intraoperative identification of small lung tumours is crucial for precise resection of these lesions during video-assisted thoracoscopic surgery. This study aimed to evaluate the feasibility and safety of indocyanine green (ICG) inhalation for intraoperative visualization of lung tumours.
methodsFrom January 2022 to May 2022, 43 patients with lung nodules were included into this study. All patients received intraoperative ICG inhalation for visualization of lung tumours under near-infrared imaging. The primary outcomes of this trial were the detection rate and background-tumour ratio of lung nodules, and the secondary objectives were time to search for nodules and operative time to nodules excision.
resultsA total of 50 pulmonary nodules in 43 patients were identified and completely resected. And 44 lung nodules were detected during intraoperative fluorescent exploration with a median inhaled ICG dose of 18.8 mg. In vivo, the median background-tumour ratio was 7.10. The median detection time of nodules was 100 s and the median operative time to nodules excision was 18 min. Quantification analysis showed that the fluorescence intensity of postoperative sputum declined to ∼10% of the first fluorescent sputum within 20 h. No adverse events attributed to ICG inhalation were recorded during the follow-up period.
conclusionsIntraoperative inhalation of ICG was a feasible and safe method for detection of lung tumours at low dose of ICG. This technique could be a remedial measure for identification of unpalpable lung nodules without preoperative localization.
trial registrationChinese Clinical Trial Registry, Identifier: ChiCTR2100053708.
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