Evidence map›Paper›PMID 37171774›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2023

Activation of Nrf-2 Transcription Factor and Caspase Pathway with Royal Jelly Reduces Fluoride Induced Testicular Damage and Infertility in Rats.

Gozde Parlak, Abdullah Aslan, Gaffari Turk, Tuncay Kuloglu, Merve Kavak Balgetir, Ozlem Gok, Seda Beyaz, Akif Evren Parlak, Serap Dayan Cinkara

Abstract read
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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gozde ParlakFaculty of Science, Department of Biology-Molecular Biology and Genetics, Firat University, Elazig, Türkiye.
Abdullah AslanFaculty of Science, Department of Biology-Molecular Biology and Genetics, Firat University, Elazig, Türkiye. aaslan@firat.edu.tr.ORCID http://orcid.org/0000-0002-6243-4221
Gaffari TurkFaculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, Firat University, Elazig, Türkiye.
Tuncay KulogluSchool of Medicine Department of Histology, Firat University, Elazig, Türkiye.
Merve Kavak BalgetirSchool of Medicine Department of Histology, Firat University, Elazig, Türkiye.
Ozlem GokFaculty of Science, Department of Biology-Molecular Biology and Genetics, Firat University, Elazig, Türkiye.
Seda BeyazFaculty of Science, Department of Biology-Molecular Biology and Genetics, Firat University, Elazig, Türkiye.
Akif Evren ParlakDepartment of Environmental Protection Technologies, Keban Vocational School, Firat University, Elazig, Türkiye.
Serap Dayan CinkaraFaculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, Firat University, Elazig, Türkiye.
Fırat University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was carried out to investigate the protective properties of royal jelly on the testicular tissue of rats with testicular damage by giving fluoride. Sperm motility, epididymal sperm density and abnormal sperm ratios were examined and visualized with a light microscope. Expression levels of Caspase-3, Bcl-2, Nrf-2, NF-κB, COX-2, TNF-α and IL1-α proteins in testis tissue were determined by western blot technique. As a result of the study, MDA level, expression level of Bcl-2, NFҡB, COX-2, TNF-α and IL1-α proteins, abnormal sperm rates were found higher in Fluoride-50 and Fluoride100 groups compared to other groups. In addition GSH, Catalase enzyme levels, expression levels of Caspase-3 and Nrf-2 proteins were found to be higher in Fluoride + Royal Jelly groups compared to Fluoride-50 and Fluoride-100 groups. In addition, lower degeneration of testicular tissue was found in the histological evaluation in the Fluoride + Royal Jelly groups compared to the other groups. When the data are evaluated royal jelly provides effective protection against testicular damage. From this point of view, we hope that similar results will be obtained when royal jelly is tested on humans.

Indexed as

InfertilityTestisAnimalsAntioxidantsCaspase 3CaspasesCyclooxygenase 2FluoridesMaleOxidative StressProto-Oncogene Proteins c-bcl-2RatsRoyal JellySemenSperm MotilityTranscription FactorsAntioxidantsCaspase 3CaspasesCyclooxygenase 2FluoridesProto-Oncogene Proteins c-bcl-2Royal JellyTranscription FactorsTumor Necrosis Factor-alphaFluorideProteinsRoyal jellySperm parametersTesticular damage

Identifiers

PMID37171774
OpenAlexW4376225373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.