Evidence map›Paper›PMID 37171719›Full record

ArticleAmino acids2023

P19-derived neuronal cells express H

Mariela Gomez Perez, Georgiana Tanasie, Armelle Tchoumi Neree, Narjara Gonzalez Suarez, Clara Lafortune, Joanne Paquin, Lucia Marcocci, Paola Pietrangeli, Borhane Annabi, Mircea Alexandru Mateescu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mariela Gomez PerezDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Georgiana TanasieDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Armelle Tchoumi NereeDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Narjara Gonzalez SuarezDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Clara LafortuneDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Joanne PaquinDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Lucia MarcocciDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185, Rome, Italy.
Paola PietrangeliDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, 00185, Rome, Italy.
Borhane AnnabiDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada.
Mircea Alexandru MateescuDepartment of Chemistry and CERMO FC Center, Université du Québec à Montréal, C. P. 8888, Montréal, QC, H3C 3P8, Canada. mateescu.m-alexandru@uqam.ca.
Université du Québec à Montréal · CASapienza University of Rome · IT

Funding

Natural Sciences and Engineering Research Council of Canada 06651Natural Sciences and Engineering Research Council of Canada 06919
6 · The paper itself

Abstract

Histamine is a biogenic amine implicated in various biological and pathological processes. Convenient cellular models are needed to screen and develop new antihistamine agents. This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H

Indexed as

Amine Oxidase (Copper-Containing)Biological ProductsAnimalsCatalaseCimetidineHistamineHistamine AntagonistsHistamine H1 AntagonistsHydrogen PeroxideLoratadineMiceNeuronsReceptors, HistamineAmine Oxidase (Copper-Containing)Biological ProductsCatalaseCimetidinedesloratadineHistamineHistamine AntagonistsHistamine H1 AntagonistsHydrogen PeroxideLoratadineReceptors, HistamineAntihistamine drugsBiogenic amineCatalaseCimetidineCiproxifanCopper-containing diamine oxidaseDesloratadineHistamineHistamine receptorsP19 embryonic carcinoma cells

Identifiers

PMID37171719
PMCPMC10287827
OpenAlexW4376225150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.