Evidence map›Paper›PMID 37171634›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

The use of single-timepoint images to link administered radioiodine activity (MBq) to a prescribed lesion radiation-absorbed dose (cGy): a regression-based prediction interval tool for the management of well-differentiated thyroid cancer patients.

Audrey Mauguen, Ravinder K Grewal, Finn Augensen, Murad Abusamra, Sonia Mahajan, Vetri Sudar Jayaprakasam, Joseph Osborne, Sofia Haque, Bernadette Z Y Wong, Ronald A Ghossein and 6 more

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase I
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03647358 phase1recruitingnot on this map

Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma

TypeinterventionalSponsorMemorial Sloan Kettering Cancer CenterRan2018 to 2027Enrolled60ConditionsThyroid Carcinoma, Metastatic Thyroid CarcinomaArmsPET/CT Scan, Iodine-124
NCT04462471 phase1completednot on this map

A Phase Ib Trial of Vemurafenib Plus Copanlisib to Enhance Radioiodine Avidity in Radioiodine-Refractory Thyroid Cancers

TypeinterventionalSponsorMemorial Sloan Kettering Cancer CenterRan2020 to 2023Enrolled8ConditionsThyroid Carcinoma, Thyroid Cancer, Thyroid Cancer, Follicular, Thyroid Cancer (Follicular Cell)ArmsI-124 PET/CT lesion dosimetry, Vemurafenib, Copanlisib
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Dose-activity relationship in [Annals of nuclear medicine · 2026
    Article
  3. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  4. Advances in Radioligand Theranostics in Oncology.Molecular diagnosis & therapy · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Audrey MauguenDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ravinder K GrewalDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Finn AugensenDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Murad AbusamraDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Sonia MahajanDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Vetri Sudar JayaprakasamDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Joseph OsborneDivision of Molecular Imaging and Therapeutics, Weill Cornell Medical College, New York, NY, USA.
Sofia HaqueDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Bernadette Z Y WongDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
Ronald A GhosseinDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
James FaginDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Heiko SchӧderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA.
R Michael TuttleDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alan HoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 415 East 68th Street, Z-2064, New York, NY, 10065, USA. larsons@mskcc.org.ORCID 0000-0002-6111-7507
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
124I-NaI PET: Building block for precision medicine in metastatic thyroid cancerR01CA201250 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HUMM, JOHN L, LARSON, STEVEN MARK · 2016 to 2020
$3.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA201250
6 · The paper itself

Abstract

purposeTo introduce a biomarker-based dosimetry method for the rational selection of a treatment activity for patients undergoing radioactive iodine

methodsPatients referred for RAI therapy of mDTC were enrolled in institutionally approved protocols. A total of 208 mDTC lesions (in 21 patients) with SUV

resultsIn the 169 lesions (in 15 patients) that received

conclusionsBased on MIRD lesion-absorbed dose estimates and regression statistics, we report on the feasibility of a new single-timepoint

trial registrationNCT04462471, Registered July 8, 2020. NCT03647358, Registered Aug 27, 2018.

Indexed as

AdenocarcinomaThyroid NeoplasmsCadaverineHumansIodine RadioisotopesRadiation DosageCadaverineIodine-124Iodine-131Iodine RadioisotopesmonodansylthiacadaverineDifferentiated thyroid cancerDosimetryIodine-124PET/CTRadioactive iodine therapy

Identifiers

PMID37171634
PMCPMC10382352
OpenAlexW4376224484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.