SynthesisEuropean radiology2023
Delayed post gadolinium MRI descriptors for Meniere's disease: a systematic review and meta-analysis.
Synthesis in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Task force of the Brazilian Society of Otology and the Brazilian Academy of Neurotology: Menière's Disease.Brazilian journal of otorhinolaryngology · 2026Review
- Human-AI collaboration using GPT-5 for MR grading of endolymphatic hydrops in Ménière's disease.European radiology · 2026Article
- Frequency- and time-dependent hearing improvement after glycerol administration in suspected Ménière's disease: a secondary analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Association between endolymphatic hydrops severity and audio-vestibular outcomes in Ménière's disease: A systematic review and meta-analysis of correlation coefficients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Patient-Level Modeling of Ménière's Disease vs. Vestibular Migraine: Performance of Speech Discrimination and Caloric-vHIT Dissociation.Journal of clinical medicine · 2026Article
- 7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière's disease and endolymphatic hydrops: an exploratory study.BMC medical imaging · 2025Observational
- Optical coherence tomography imaging demonstrates endolymphatic hydrops in the lateral and posterior semicircular canals in noise-exposed mice.Hearing research · 2025Article
- Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss.Science translational medicine · 2025Article
- A diagnostic model based on magnetic resonance imaging for Menière’s disease: a multicentre studyDiagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Clinical significance of endolymphatic hydrops on MRI in Cogan's syndrome: a case series of five patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Imaging endolymphatic space of the inner ear in vestibular migraine.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- 3T-3D FLAIR MRI in Menière's disease: associated profiles with clinical symptoms and electroacoustic characteristics.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The impact of 3D real-IR delayed post gadolinium MRI parameterisation on the diagnostic performance and optimal descriptor selection in Ménière's disease.European radiology · 2025Article
- The Utility of Contrast-Enhanced 3D-Real Inversion Recovery Magnetic Resonance Imaging in the Diagnosis of Endolymphatic Hydrops-A Retrospective Study of a Newly Implemented Clinical Service at a Tertiary Center.The journal of international advanced otology · 2025Article
- Role of hydrops MRI in differentiating between Menière's disease and vestibular migraine: a prospective study.Frontiers in neurology · 2025Article
- Magnetic resonance imaging evaluation of cochlear and vestibular nerve calibre: a case-control study in Ménière's disease and endolymphatic hydrops.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- A modern conceptual framework for study and treatment of Meniere's disease.Frontiers in neurology · 2025Review
- A review of Meniere's disease - reflection of published MRI, ECochG and newer otoconial theory from Aotearoa New Zealand.Journal of the Royal Society of New Zealand · 2025Article
- Synergistic role of blood-labyrinth barrier permeability and endolymphatic hydrops: a comparative perspective in Ménière's disease and vestibular migraine.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesDelayed post-gadolinium magnetic resonance imaging (MRI) detects changes of endolymphatic hydrops (EH) within the inner ear in Meniere's disease (MD). A systematic review with meta-analysis was conducted to summarise the diagnostic performance of MRI descriptors across the range of MD clinical classifications. MATERIALS AND
methodsCase-controlled studies documenting the diagnostic performance of MRI descriptors in distinguishing MD ears from asymptomatic ears or ears with other audio-vestibular conditions were identified (MEDLINE, EMBASE, Web of Science, Scopus databases: updated 17/2/2022). Methodological quality was evaluated with Quality Assessment of Diagnostic Accuracy Studies version 2. Results were pooled using a bivariate random-effects model for evaluation of sensitivity, specificity and diagnostic odds ratio (DOR). Meta-regression evaluated sources of heterogeneity, and subgroup analysis for individual clinical classifications was performed.
resultsThe meta-analysis included 66 unique studies and 3073 ears with MD (mean age 40.2-67.2 years), evaluating 11 MRI descriptors. The combination of increased perilymphatic enhancement (PLE) and EH (3 studies, 122 MD ears) achieved the highest sensitivity (87% (95% CI: 79.92%)) whilst maintaining high specificity (91% (95% CI: 85.95%)). The diagnostic performance of "high grade cochlear EH" and "any EH" descriptors did not significantly differ between monosymptomatic cochlear MD and the latest reference standard for definite MD (p = 0.3; p = 0.09). Potential sources of bias were case-controlled design, unblinded observers and variable reference standard, whilst differing MRI techniques introduced heterogeneity.
conclusionsThe combination of increased PLE and EH optimised sensitivity and specificity for MD, whilst some MRI descriptors also performed well in diagnosing monosymptomatic cochlear MD. KEY POINTS: • A meta-analysis of delayed post-gadolinium magnetic resonance imaging (MRI) for the diagnosis of Meniere's disease is reported for the first time and comprised 66 studies (3073 ears). • Increased enhancement of the perilymphatic space of the inner ear is shown to be a key MRI feature for the diagnosis of Meniere's disease. • MRI diagnosis of Meniere's disease can be usefully applied across a range of clinical classifications including patients with cochlear symptoms alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.