ArticleImmunity & ageing : I & A2023
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging.
Article in Immunity & ageing : I & A, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Ultrastructural Organization of Epididymis in the Cattle Egret (Bubulcus ibis) During Breeding Season.Anatomia, histologia, embryologia · 2026Article
- CX3CR1-mediated immune networks in sepsis: implications for precision therapy.Cell death discovery · 2026Review
- A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging.Aging cell · 2025Article
- Single-Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing.Cell proliferation · 2025Article
- Identification of hub genes associated with decreased fertility in male mice of advanced paternal age.Frontiers in cell and developmental biology · 2025Article
- Single-cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila.Aging cell · 2024Article
- The significance of single-cell transcriptome analysis in epididymis research.Frontiers in cell and developmental biology · 2024Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMorphological and functional alterations in aging reproductive organs result in decreased male fertility. The epididymis functions as the transition region for post-testicular sperm maturation. And we have previously demonstrated that the epididymal initial segment (IS), a region of the reproductive tract essential for sperm maturation and capacitation, undergoes considerable histological changes and chronic immune activation in mice during aging. However, the local aging-associated cellular and molecular changes in the aged epididymal IS are poorly understood.
resultsWe conducted single-cell RNA sequencing analysis on the epididymal IS of young (3-month-old) and old (21-month-old) mice. In total, 10,027 cells from the epididymal IS tissues of young and old mice were obtained and annotated. The cell composition, including the expansion of a principal cell subtype and Ms4a4b
conclusionContrary to the general pattern of lower immune responses in the male proximal genital tract, we revealed an inflammaging status in mouse epididymal initial segment. These findings will allow future studies to enable the delay of male reproductive aging via immune regulation.
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