Evidence map›Paper›PMID 37170272›Full record

ArticleItalian journal of pediatrics2023

Role of abnormal glycosylated IgA1 and interstitial transformation of glomerular endothelial cells in the development and progression of IgA nephropathy.

Wanyu Jia, Wenjie Dou, Qin Wang, Huiqin Zeng, Peipei Shi, Jing Liu, Zhen Liu, Jin Zhang, Jian-Jiang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wanyu JiaDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Wenjie DouDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Qin WangDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Huiqin ZengDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Peipei ShiDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Jing LiuDepartment of Nephrology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Zhen LiuDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Jin ZhangDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China.
Jian-Jiang ZhangDepartment of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan Province, China. zhangjianjiang1@hotmail.com.
First Affiliated Hospital of Zhengzhou University · CNTongji University · CN

Funding

Henan Provincial Science and Technology Research Project SBGJ202003050Key Scientific Research Project of Colleges and Universities in Henan Province 21A320070
6 · The paper itself

Abstract

backgroundIgA nephropathy (IgAN) is a common primary renal disease in childhood.

methodsTwenty blood samples and renal tissue from patients with IgAN, 20 blood samples from healthy children and 10 normal renal tissue were collected. Serum Gd-IgA1 and renal Gd-IgA1, CD31, α-SMA and vimentin were measured.

resultsThe serum Gd-IgA1 concentration in the IgAN group was significantly higher. Gd-IgA1 was not expressed in normal kidneys, which was positive in the IgAN group. Gd-IgA1 levels in serum and renal tissue were not related. The expression of CD31 decreased significantly in IgAN group, while the expression of α-SMA and vimentin increased significantly. There was no significant correlation between the renal concentration of Gd-IgA1 and CD31, α-SMA and vimentin.

conclusionThe increased Gd-IgA1 in the serum and kidney may promote the pathogenesis of IgAN. The serum Gd-IgA1 cannot predict the extent of its deposition in the kidney. Endothelial mesenchymal transition (EndMT) may be involved in the pathogenesis of renal fibrosis in IgAN.

Indexed as

Glomerulonephritis, IGAChildEndothelial CellsHumansImmunoglobulin AKidneyVimentinImmunoglobulin AVimentinAbnormally glycosylated IgA1Endothelial cell interstitial transformationIgA nephropathyPathogenesisRenal fibrosis

Identifiers

PMID37170272
PMCPMC10173471
OpenAlexW4376137925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.