Evidence map›Paper›PMID 37170253›Full record

ArticleBMC cardiovascular disorders2023

An acute increase in Left Atrial volume and left ventricular filling pressure during Adenosine administered myocardial hyperaemia: CMR First-Pass Perfusion Study.

Pankaj Garg, Wasim Javed, Hosamadin Assadi, Samer Alabed, Ciaran Grafton-Clarke, Andrew J Swift, Gareth Williams, Abdallah Al-Mohammad, Chris Sawh, Vassilios S Vassiliou and 5 more

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In one paragraph

Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Pankaj GargUniversity of East Anglia, Norwich Medical School, Norwich, Norfolk, UK. p.garg@uea.ac.uk.
Wasim JavedLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Hosamadin AssadiUniversity of East Anglia, Norwich Medical School, Norwich, Norfolk, UK.
Samer AlabedDepartment of Infection, Immunity and Cardiovascular disease, University of Sheffield Medical School and Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Ciaran Grafton-ClarkeUniversity of East Anglia, Norwich Medical School, Norwich, Norfolk, UK.
Andrew J SwiftDepartment of Infection, Immunity and Cardiovascular disease, University of Sheffield Medical School and Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Gareth WilliamsDepartment of Infection, Immunity and Cardiovascular disease, University of Sheffield Medical School and Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Abdallah Al-MohammadDepartment of Infection, Immunity and Cardiovascular disease, University of Sheffield Medical School and Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Chris SawhNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, UK.
Vassilios S VassiliouUniversity of East Anglia, Norwich Medical School, Norwich, Norfolk, UK.
Mohammed Y KhanjiNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Fabrizio RicciDepartment of Neuroscience, Imaging and Clinical Sciences, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
John P GreenwoodLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Sven PleinLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Peter SwobodaNorwich Medical School, Norwich Research Park, Norwich, NR4 7UQ, UK.ORCID 0000-0002-5483-169X
Sheffield Teaching Hospitals NHS Foundation Trust · GBUniversity of East Anglia · GBUniversity of Leeds · GBNorfolk and Norwich University Hospitals NHS Foundation Trust · GBNorwich Research Park · GBSt Bartholomew's Hospital · GBUniversity of Chieti-Pescara · IT

Funding

Wellcome TrustWellcome Trust 205188/Z/16/ZWellcome Trust 220703/Z/20/Z
6 · The paper itself

Abstract

objectiveTo investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia as part of a first-pass stress perfusion study. METHODS AND

resultsWe enrolled 33 patients who had stress CMR. These patients had a baseline four-chamber cine and stress four-chamber cine, which was done at peak myocardial hyperaemic state after administering adenosine. The left and right atria were segmented in the end ventricular diastolic and systolic phases. Short-axis cine stack was segmented for ventricular functional assessment. At peak hyperaemic state, left atrial end ventricular systolic volume just before mitral valve opening increased significantly from baseline in all (91 ± 35ml vs. 81 ± 33ml, P = 0.0002), in males only (99 ± 35ml vs. 88 ± 33ml, P = 0.002) and females only (70 ± 26ml vs. 62 ± 22ml, P = 0.02). The right atrial end ventricular systolic volume increased less significantly from baseline (68 ± 21ml vs. 63 ± 20ml, P = 0.0448). CMR-derived LVFP (equivalent to pulmonary capillary wedge pressure) increased significantly at the peak hyperaemic state in all (15.1 ± 2.9mmHg vs. 14.4 ± 2.8mmHg, P = 0.0002), females only (12.9 ± 2.1mmHg vs. 12.3 ± 1.9mmHg, P = 0.029) and males only (15.9 ± 2.8mmHg vs. 15.2 ± 2.7mmHg, P = 0.002) cohorts.

conclusionLeft atrial volume assessment by CMR can measure acute and dynamic changes in preloading conditions on the left ventricle. During adenosine administered first-pass perfusion CMR, left atrial volume and LVFP rise significantly.

Indexed as

Atrial FibrillationHyperemiaFemaleHeart AtriaHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMalePerfusionStroke VolumeVentricular Function, LeftCardiovascular magnetic resonanceHaemodynamicsLeft atriumLeft ventricular end-diastolic pressureMRI

Identifiers

PMID37170253
PMCPMC10176699
OpenAlexW4376225595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.