Article in Reproductive biology and endocrinology : RB&E, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 32 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 3 institutions in 1 country.
Mike R WilsonDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0002-7681-2457
Shannon HarkinsDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Jake J ReskeDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Rebecca A SiwickiGenomics Core Facility, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Marie AdamsGenomics Core Facility, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Victoria L Bae-JumpLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jose M TeixeiraDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA.
Ronald L ChandlerDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, 49503, USA. rlc@msu.edu.ORCID http://orcid.org/0000-0001-5775-2594
Michigan State University · USVan Andel Institute · USUniversity of North Carolina at Chapel Hill · US
Funding
Epigenetic regulatory mechanisms and therapeutic opportunities in endometriosisR01HD103617 · NICHD · MICHIGAN STATE UNIVERSITY · PI CHANDLER, RONALD L · 2021 to 2025
$1.7M
Does obesity influence protein quality control in endometrial cancer?R00CA252152 · NCI · WAYNE STATE UNIVERSITY · PI WILSON, MICHAEL R · 2023 to 2025
$747k
Role of chromatin remodeling and cell signaling in endometriosis etiologyR21HD099383 · NICHD · MICHIGAN STATE UNIVERSITY · PI CHANDLER, RONALD L · 2019 to 2020
$430k
Does obesity influence protein quality control in endometrial cancer?K99CA252152 · NCI · MICHIGAN STATE UNIVERSITY · PI WILSON, MICHAEL R · 2021 to 2022
Endometrial epithelia are known to harbor cancer driver mutations in the absence of any pathologies, including mutations in PIK3CA. Insulin plays an important role in regulating uterine metabolism during pregnancy, and hyperinsulinemia is associated with conditions impacting fertility. Hyperinsulinemia also promotes cancer, but the direct action of insulin on mutated endometrial epithelial cells is unknown. Here, we treated 12Z endometriotic epithelial cells carrying the PIK3CA
Indexed as
HyperinsulinismNeoplasmsClass I Phosphatidylinositol 3-KinasesEndometriumEpithelial CellsFemaleHumansInsulinInterferonsMutationClass I Phosphatidylinositol 3-KinasesInsulinInterferonsPIK3CA protein, humanEndometriumEndoplasmic reticulum stressInsulinInterferonPhosphatidylinositide 3-kinase
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin. · full record | OpenQuestion