ArticleCommunications chemistry2023
Boron-assisted abiotic polypeptide synthesis.
Article in Communications chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification.ACS bio & med chem Au · 2025Article
- The Origin of Life and Cellular Systems: A Continuum from Prebiotic Chemistry to Biodiversity.Life (Basel, Switzerland) · 2025Article
- Reproducible Ala-Gly oligomerization catalyzed by the natural Borate colemanite in prebiotic conditions.Scientific reports · 2025Article
- On the Roles of Protein Intrinsic Disorder in the Origin of Life and Evolution.Life (Basel, Switzerland) · 2024Review
- Amino acid analogues provide multiple plausible pathways to prebiotic peptides.Journal of the Royal Society, Interface · 2024Review
- The Mystery of Homochirality on Earth.Life (Basel, Switzerland) · 2024Review
- Atmospheric formaldehyde production on early Mars leading to a potential formation of bio-important molecules.Scientific reports · 2024Article
- Hexose phosphorylation for a non-enzymatic glycolysis and pentose phosphate pathway on early Earth.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The emergence of proteins and their interactions with RNAs were a key step in the origin and early evolution of life. The abiotic synthesis of peptides has been limited in short amino acid length and is favored in highly alkaline evaporitic conditions in which RNAs are unstable. This environment is also inconsistent with estimated Hadean Earth. Prebiotic environments rich in boron are reportedly ideal for abiotic RNA synthesis. However, the effects of boron on amino acid polymerization are unclear. We report that boric acid enables the polymerization of amino acids at acidic and near-neutral pH levels based on simple heating experiments of amino acid solutions containing borate/boric acid at various pH levels. Our study provides evidence for the boron-assisted synthesis of polypeptides in prebiotically plausible environments, where the same conditions would allow for the formation of RNAs and interactions of primordial proteins and RNAs that could be inherited by RNA-dependent protein synthesis during the evolution of life.
Identifiers
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Registered trials
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