ArticleNature medicine2023
Accelerated waning of the humoral response to COVID-19 vaccines in obesity.
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Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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0cells of the map it votes in
68citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 96 citations in OpenAlex.
- Polypore mushroom mycelia as an adjunct to COVID-19 vaccination: a randomized clinical trial.BMC immunology · 2026Trial
- Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node-Targeting and Augments mRNA Vaccine Efficacy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1-nCoV-19 Vaccine in Hemodialysis Patients.The Kaohsiung journal of medical sciences · 2026Article
- Host Immune Responses to SARS-CoV-2 Vaccination in Northern Mexico: Structural Biology Insights and the Impact of Obesity.International journal of molecular sciences · 2026Article
- SARS-CoV-2 intra-host viral diversity associated with host innate and vaccine-induced immunity in an obese mouse model.BMC infectious diseases · 2026Article
- Adherence to the Mediterranean diet, particularly olive oil intake, and metabolic health parameters are independently associated with SARS-CoV-2 vaccine-induced IgG responses.Metabolism open · 2026Article
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Article
- The Decline in Influenza Antibody Titers and Modifiers of Vaccine Immunity from over Ten Years of Serological Data.medRxiv : the preprint server for health sciences · 2026Article
- SARS-CoV-2 humoral immunity is associated with elevated hemoglobin A1c.Laboratory medicine · 2026Article
- Post-vaccination SARS-CoV-2 infections and antibody responses after BNT162b2 in patients with severe obesity: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Capsaicin attenuates high-fat diet-induced impairment of B-cell immunity.SAGE open medicine · 2026Article
- Multifaceted B cell response to transient HIV viremia in elite controllers.PLoS pathogens · 2026Article
- Impact of obesity on COVID-19 CoronaVac and ChAdOx1-S vaccine efficacy.BMC infectious diseases · 2025Article
- Article
- Immunology of RNA-based vaccines: The critical interplay between inflammation and expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes.European journal of immunology · 2025Article
- Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination.NPJ vaccines · 2025Article
- CD11c+ Tbet+ B cells constrain obesity- and vaccination-induced germinal center B cells and T helper cells.bioRxiv : the preprint server for biology · 2025Article
- A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity.iScience · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 10 institutions in 2 countries.
Agatha A van der KlaauwUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6971-8828
Emily C Horner *MRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2226-1028
Pehuén Pereyra-Gerber *Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
Utkarsh Agrawal *Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5181-6120
William S FosterBabraham Institute, Babraham Research Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-7103-3657
Sarah SpencerMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Bensi VergeseUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Miriam SmithUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Elana HenningUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Isobel D RamsayCambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9954-2023
Jack A SmithCambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6654-5706
Stephane M GuillaumeBabraham Institute, Babraham Research Campus, Cambridge, UK.ORCID http://orcid.org/0000-0003-2007-4608
Hayley J SharpeBabraham Institute, Babraham Research Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-4723-298X
Iain M HayBabraham Institute, Babraham Research Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-5451-1768
Sam ThompsonBabraham Institute, Babraham Research Campus, Cambridge, UK.
Silvia InnocentinBabraham Institute, Babraham Research Campus, Cambridge, UK.
Lucy H BoothMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Chris RobertsonDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, UK.
Colin McCowanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9466-833X
Steven KerrUsher Institute, University of Edinburgh, Edinburgh, UK.
Thomas E MulroneyMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Martin J O'ReillyMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1095-0328
Thevinya P GurugamaMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Lihinya P GurugamaMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Maria A RustMRC Toxicology Unit, University of Cambridge, Cambridge, UK.
Alex FerreiraMRC Toxicology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1964-1049
Soraya EbrahimiImmunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Lourdes Ceron-GutierrezImmunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Jacopo ScotucciUniversity of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Barbara KronsteinerPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0867-2867
Susanna J DunachiePeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5665-6293
Paul KlenermanPeter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4307-9161
PITCH Consortium
Adrian J ParkClinical Biochemistry, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID http://orcid.org/0000-0003-2713-7595
Francesco RubinoDepartment of Diabetes, King's College London and King's College Hospital NHS Foundation Trust, London, UK.
Abigail A LamikanraNHS Blood and Transplant, Oxford, UK.
Hannah StarkNIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Nathalie KingstonNIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Lise EstcourtNHS Blood and Transplant, Oxford, UK.
Heli HarvalaNHS Blood and Transplant, London, UK.
David J RobertsNHS Blood and Transplant, Oxford, UK.
Rainer DoffingerImmunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Michelle A LintermanBabraham Institute, Babraham Research Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-6047-1996
Nicholas J Matheson *Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3318-1851
Aziz Sheikh *Usher Institute, University of Edinburgh, Edinburgh, UK. aziz.sheikh@ed.ac.uk.ORCID http://orcid.org/0000-0001-7022-3056
I Sadaf Farooqi *University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Cambridge, UK. isf20@cam.ac.uk.ORCID http://orcid.org/0000-0001-7609-3504
James E D Thaventhiran *MRC Toxicology Unit, University of Cambridge, Cambridge, UK. jedt2@cam.ac.uk.ORCID http://orcid.org/0000-0001-8616-074X
University of Cambridge · GBBabraham Institute · GBCambridge University Hospitals NHS Foundation Trust · GBNHS Blood and Transplant · GBUniversity of Oxford · GBUniversity of Edinburgh · GBKing's College London · GBMRC Epidemiology Unit · GBUniversity of Strathclyde · GBWellcome/MRC Institute of Metabolic Science · GB
Funding
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MBiotechnology and Biological Sciences Research Council BBS/E/B/000C0427Biotechnology and Biological Sciences Research Council BBS/E/B/000C0428Biotechnology and Biological Sciences Research Council BBS/E/B/000C0433Medical Research Council MC_PC_19004Medical Research Council MC_PC_19075Medical Research Council MC_PC_20058Medical Research Council MC_UU_0025/12Medical Research Council MR/T032413/1Medical Research Council MR/W020564/1Medical Research Council MR/X009297/1MRF_ MRF-057-0002-RG-THAV-C0798NIAID NIH HHS U19 AI082630Wellcome TrustWellcome Trust 204845/Z/16/ZWellcome Trust 208363/Z/17/ZWellcome Trust WT109965MA
Abstract
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people with obesity is incompletely understood. We studied the relationship among body mass index (BMI), hospitalization and mortality due to COVID-19 among 3.6 million people in Scotland using the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) surveillance platform. We found that vaccinated individuals with severe obesity (BMI > 40 kg/m
Indexed as
COVID-19Obesity, MorbidAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesHumansLongitudinal StudiesObesityProspective StudiesSARS-CoV-2VaccinationAntibodies, NeutralizingAntibodies, ViralCOVID-19 Vaccines
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.