ArticleNature neuroscience2023
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.
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Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
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58 citing papers in PubMed, 89 citations in OpenAlex.
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- Integrated multi-omics identifies macrophage ARG1-mediated deacetylation with causal and diagnostic implications in ischemic stroke.iScience · 2026Article
- Lactate modulates microglial M2 polarizationJournal of translational internal medicine · 2026Article
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- A Comprehensive Analysis of Inflammation Regulatory Biomarkers among three Neuropsychiatric Disorders using Transcriptomic Approach.Neuroinformatics · 2026Article
- ARG1 Inhibition after Neonatal Hypoxic-Ischemic Brain Injury.Developmental neuroscience · 2026Article
- Sustained Transcriptional Response to Lipopolysaccharide and Interleukin-4 in an Immortalized Mouse Microglial Cell Line.Molecular neurobiology · 2026Article
- Article
- Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Focus on Arginase.Cells · 2026Article
- ARG1-polyamine axis: cell-type-specific functions in disease pathogenesis and therapeutic targeting.Frontiers in immunology · 2026Review
- Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1.The EMBO journal · 2026Article
- Chorioamnionitis Induces a Unique Time Course of Inflammatory Changes and Immune Reponses in the Brain and Spleen.Developmental neuroscience · 2026Article
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Authors and funding
32 authors at 11 institutions in 7 countries.
Vassilis StratouliasInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden. vassilis.stratoulias@ki.se.ORCID http://orcid.org/0000-0002-9724-6589
Rocío RuizInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.ORCID http://orcid.org/0000-0001-5142-9972
Shigeaki Kanatani *Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2226-4288
Ahmed M Osman *Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Lily Keane *Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Jose A ArmengolDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.ORCID http://orcid.org/0000-0002-9452-7828
Antonio Rodríguez-MorenoDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.ORCID http://orcid.org/0000-0002-8078-6175
Adriana-Natalia MurgociInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Irene García-DomínguezInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.ORCID http://orcid.org/0000-0001-6668-1599
Isabel Alonso-BellidoInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.
Fernando González IbáñezDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.ORCID http://orcid.org/0000-0003-3330-437X
Katherine PicardDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.ORCID http://orcid.org/0000-0003-4891-1498
Guillermo Vázquez-CabreraInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Mercedes Posada-PérezInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Nathalie VernouxDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.
Dario TejeraDepartment of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany.
Kathleen GrabertInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5628-9400
Mathilde CherayInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7551-6357
Patricia González-RodríguezInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden.
Eva M Pérez-VillegasDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.
Irene Martínez-GallegoDepartment of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain.
Alejandro Lastra-RomeroDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
David BrodinBioinformatics and Expression Analysis Core Facility, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1768-6761
Javier Avila-CariñoDepartment of Molecular Biology and Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Yang CaoClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.ORCID http://orcid.org/0000-0002-3552-9153
Mikko AiravaaraNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2026-1609
Per UhlénDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Michael T HenekaLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.ORCID http://orcid.org/0000-0003-4996-1630
Marie-Ève TremblayDepartment of Molecular Medicine, Université Laval, and Axe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Laval, Quebec, Canada.ORCID http://orcid.org/0000-0003-2863-9626
Klas BlomgrenDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0476-7271
Jose L VeneroInstituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.ORCID http://orcid.org/0000-0003-1137-8706
Bertrand JosephInstitute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden. bertrand.joseph@ki.se.ORCID http://orcid.org/0000-0001-5655-9979
Karolinska Institutet · SEInstituto de Biomedicina de Sevilla · ESUniversidad Pablo de Olavide · ESUniversity of Victoria · CAUniversity of Helsinki · FIKarolinska University Hospital · SEÖrebro University · SEUmeå University · SEUniversité Laval · CAUniversity of Bonn · DEUniversity of Massachusetts Chan Medical School · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1
Indexed as
ArginaseMicrogliaAnimalsFemaleHippocampusMiceArg1 protein, mouseArginase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.