ArticleScientific reports2023
Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA).
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prediction of non-responders to oral appliance treatment of obstructive sleep apnea: a pilot study.Sleep & breathing = Schlaf & Atmung · 2025Trial
- Altered Cerebellar Spontaneous Activity and Its Association with Arousal Index in Comorbid Insomnia and Obstructive Sleep Apnea: A Resting-State fMRI Study.Journal of clinical medicine · 2026Article
- Respiratory effort burden measured by mandibular jaw movements as a digital marker with clinical insights in obstructive sleep apnea.Communications medicine · 2026Article
- Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms.Nature and science of sleep · 2026Review
- Clinical and polysomnographic characteristics of Asian patients with comorbid insomnia and obstructive sleep apnea.Scientific reports · 2025Article
- Arousal Threshold Score: A New Indicator for Examining the Relationship Between Obstructive Sleep Apnea and Overlap Syndrome - A Retrospective Study.Nature and science of sleep · 2025Article
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Authors and funding
8 authors.
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Abstract
Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO
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