ArticleScientific reports2023
Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 12 citations in OpenAlex.
- Large cranial windows distort auditory cortical maps and degrade feature integration in secondary auditory cortex.iScience · 2026Article
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
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- Large cranial windows distort sensory maps and degrade feature integration in higher-order cortex.bioRxiv : the preprint server for biology · 2026Article
- Differential Myeloarchitecture of Subfields of the Mammalian Auditory Cortex: A Comparative Approach.Brain, behavior and evolution · 2026Review
- Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Noncanonical short-latency auditory pathway directly activates deep cortical layers.Nature communications · 2025Article
- Reduced Neural Responses to Natural Foreground versus Background Sounds in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Article
- Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Movement-related modulation in mouse auditory cortex is widespread yet locally diverse.bioRxiv : the preprint server for biology · 2023Article
- Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex.Frontiers in neural circuits · 2023Article
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3 authors at 1 institution in 1 country.
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Abstract
Animals sense sounds through hierarchical neural pathways that ultimately reach higher-order cortices to extract complex acoustic features, such as vocalizations. Elucidating how spectrotemporal integration varies along the hierarchy from primary to higher-order auditory cortices is a crucial step in understanding this elaborate sensory computation. Here we used two-photon calcium imaging and two-tone stimuli with various frequency-timing combinations to compare spectrotemporal integration between primary (A1) and secondary (A2) auditory cortices in mice. Individual neurons showed mixed supralinear and sublinear integration in a frequency-timing combination-specific manner, and we found unique integration patterns in these two areas. Temporally asymmetric spectrotemporal integration in A1 neurons suggested their roles in discriminating frequency-modulated sweep directions. In contrast, temporally symmetric and coincidence-preferring integration in A2 neurons made them ideal spectral integrators of concurrent multifrequency sounds. Moreover, the ensemble neural activity in A2 was sensitive to two-tone timings, and coincident two-tones evoked distinct ensemble activity patterns from the linear sum of component tones. Together, these results demonstrate distinct roles of A1 and A2 in encoding complex acoustic features, potentially suggesting parallel rather than sequential information extraction between these regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.