ArticleNature communications2023
Task-specific modulation of corticospinal neuron activity during motor learning in mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.Cellular and molecular life sciences : CMLS · 2026Article
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.Nature communications · 2026Article
- Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism.bioRxiv : the preprint server for biology · 2026Article
- Lateralized excitation-inhibition rebalance correlates with motor recovery following hemispheric surgery.Brain communications · 2026Article
- Evolutionary expansion of the corticospinal system is linked to dexterity inbioRxiv : the preprint server for biology · 2025Article
- Neuropathic Pain-Like Responses in a Chronic CNS Injury Model Are Mediated by Corticospinal-Targeted Spinal Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A novel biomechanical model of the proximal mouse forelimb predicts muscle activity in optimal control simulations of reaching movements.Journal of neurophysiology · 2025Article
- Neurons Are Not All the Same: Diversity in Neuronal Populations and Their Intrinsic Responses to Spinal Cord Injury.ASN neuro · 2025Review
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning.iScience · 2024Article
- Cortico-basal ganglia plasticity in motor learning.Neuron · 2024Review
- Synaptic correlates of the corticocortical circuit in motor learning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Recording Forelimb Muscle Activity in Head-Fixed Mice with Chronically Implanted EMG Electrodes.Journal of visualized experiments : JoVE · 2024Article
- Effects of noninvasive neuromodulation targeting the spinal cord on early learning of force control by the digits.CNS neuroscience & therapeutics · 2024Article
- Corticospinal Modulation of Precision Movements.Neuroscience insights · 2024Article
- Cortical circuit dynamics underlying motor skill learning: from rodents to humans.Frontiers in molecular neuroscience · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Motor skill learning relies on the plasticity of the primary motor cortex as task acquisition drives cortical motor network remodeling. Large-scale cortical remodeling of evoked motor outputs occurs during the learning of corticospinal-dependent prehension behavior, but not simple, non-dexterous tasks. Here we determine the response of corticospinal neurons to two distinct motor training paradigms and assess the role of corticospinal neurons in the execution of a task requiring precise modulation of forelimb movement and one that does not. In vivo calcium imaging in mice revealed temporal coding of corticospinal activity coincident with the development of precise prehension movements, but not more simplistic movement patterns. Transection of the corticospinal tract and optogenetic regulation of corticospinal activity show the necessity for patterned corticospinal network activity in the execution of precise movements but not simplistic ones. Our findings reveal a critical role for corticospinal network modulation in the learning and execution of precise motor movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.