Evidence map›Paper›PMID 37169351›Full record

ArticleAdvanced healthcare materials2023

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy.

Hongya Geng, Emily J Lupton, Yun Ma, Rujie Sun, Christopher L Grigsby, Giulia Brachi, Xiaorui Li, Kun Zhou, Daniel J Stuckey, Molly M Stevens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Hongya GengDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0002-4276-352X
Emily J LuptonUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, WC1E 6DD, UK.
Yun MaDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Rujie SunDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Christopher L GrigsbyDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Stockholm 171 11, Sweden.
Giulia BrachiDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Xiaorui LiTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Kun ZhouDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Daniel J StuckeyUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, WC1E 6DD, UK.
Molly M StevensDepartment of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.ORCID 0000-0002-8940-9261
NIHR Imperial Biomedical Research Centre · GBKarolinska Institutet · SEUniversity College London · GBTsinghua–Berkeley Shenzhen Institute · CN

Funding

Biotechnology and Biological Sciences Research Council BB/M009513/1British Heart Foundation FS/15/33/31608British Heart Foundation FS/SBSRF/21/31020British Heart Foundation RM/17/1/33377Medical Research Council MR/R026416/1Wellcome TrustWellcome Trust 212937/Z/18/Z
6 · The paper itself

Abstract

The development of near-infrared light responsive conductive polymers provides a useful theranostic platform for malignant tumors by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, the self-assembly of ultrathin 2D polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template is demonstrated. The 2D polypyrrole-polydopamine nanostructure has tunable size distribution which shows strong absorption in the first and second near-infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double-layer is demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 µm). The acidic environment drives reversible doping of polypyrrole, which can be detected by Raman spectroscopy. The combined properties of the nanosheets can substantially enhance performance in dual-mode Raman and photoacoustic guided photothermal therapy, as shown by the 69% light to heat conversion efficiency and higher cytotoxicity against cancer spheroids. These pH-responsive features highlight the potential of 2D conductive polymers for applications in accurate, highly efficient theranostics.

Indexed as

NanoparticlesNeoplasmsPhotoacoustic TechniquesHumansIndolesPhototherapyPhotothermal TherapyPolymersPyrrolesTheranostic NanomedicineIndolespolydopaminePolymerspolypyrrolePyrrolesconductive nanosheetsphotoacoustic imagingphotothermal therapypolypyrroleRaman imaging

Identifiers

PMID37169351
PMCPMC11468501
OpenAlexW4376223993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.