Evidence map›Paper›PMID 37169225›Full record

ArticleJournal of neuroscience methods2023

Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience.

Alan S Lewis, William P Nobis

Abstract read
In one paragraph

Article in Journal of neuroscience methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alan S LewisDepartments of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: alan.s.lewis@vumc.org.
William P NobisNeurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA.

Funding

Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
A translational approach to understand hippocampal neural circuitry regulating impulsive aggressionK23MH116339 · NIMH · YALE UNIVERSITY · PI LEWIS, ALAN SETH · 2018 to 2022
$919k
NCATS NIH HHS KL2 TR002245NIMH NIH HHS K23 MH116339
6 · The paper itself

Abstract

Replicability and reproducibility are widely considered to be cornerstones of valid scientific research. Yet, the elements of replication in fundamental neuroscience studies do not fully overlap with the process of replication in clinical neuroscience involving patients. Here we discuss how better aligning the concept of replication across this translational spectrum might enhance the rate at which basic findings in the organization and function of the nervous system are leveraged to develop new treatments for psychiatric and neurological disorders.

Indexed as

Evidence GapsNeurosciencesHumansProteomicsReproducibility of ResultsTranslational Research, BiomedicalClinical trialsNeural circuitsPsychiatryReplicabilityReproducibilityTranslational neuroscience

Identifiers

PMID37169225
PMCPMC10214459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.