Evidence map›Paper›PMID 37169119›Full record

ArticleThe Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

A Model Study to Evaluate Osseointegration and Fracture Healing Following Open Reduction and Internal Fixation (ORIF) in Diabetic Lewis Rats.

Alexandra Arteaga, Claudia Cristina Biguetti, Bhuvana Lakkasetter Chandrashekar, Jimena Mora, Adeena Qureshi, Evelin Rios, Javier La Fontaine, Danieli C Rodrigues

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandra ArteagaDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Claudia Cristina BiguettiDepartment of Surgery and Biomechanics, School of Podiatric Medicine, The University of Texas Rio Grande Valley, Harlingen, TX.
Bhuvana Lakkasetter ChandrashekarDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Jimena MoraDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Adeena QureshiDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Evelin RiosDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Javier La FontaineDepartment of Surgery and Biomechanics, School of Podiatric Medicine, The University of Texas Rio Grande Valley, Harlingen, TX.
Danieli C RodriguesDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX. Electronic address: danieli@utdallas.edu.
The University of Texas at Dallas · USThe University of Texas Rio Grande Valley · US

Funding

Understanding The Impact of Diabetes on Implant Performance: A Retrieval StudyF31DK121483 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ARTEAGA, ALEXANDRA · 2019 to 2022
$163k
NIDDK NIH HHS F31 DK121483
6 · The paper itself

Abstract

There is a higher risk of implant osseointegration failure after open reduction and internal fixation (ORIF) in patients with diabetes due to increased inflammatory conditions, associated metallic corrosion and infection. While it is possible to avoid elective osseous surgery in patients with diabetes, it may not be the case in nonelective cases, such as ORIF ankle fractures. A total of 30 male Lewis rats (12-15 weeks old) were distributed into diabetic (D) and nondiabetic (ND) groups. Fracture healing and osseointegration were evaluated at 2-, 10-, and 21-day time points. Microtomographic and histological analysis depicted distinct differences in fracture healing and osseointegration between D and ND animals. Immunohistochemical analysis exhibited elevated proliferation (PCNA) and osteogenic (Runx2) cells for ND animals, while HMGB1 (inflammatory marker) was elevated for D animals during healing. Bone resorption marker CTX-1 was elevated in the plasma of D animals at 2 days, while bone formation marker P1NP was higher for ND animals at 10 days. Overall, this model resulted in delayed implant osseointegration and fracture healing in diabetic animals, highlighting the importance of developing new biomaterials or implant coatings that can improve bone healing outcomes in this patient population.

Indexed as

Diabetes MellitusOsseointegrationAnimalsFracture Fixation, InternalFracture HealingHumansMaleOpen Fracture ReductionProstheses and ImplantsRatsRats, Inbred LewTitaniumTitaniumhyperglycemiaimplantsorthopedicsrodenttitanium

Identifiers

PMID37169119
PMCPMC11292579
OpenAlexW4376224748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.