Evidence map›Paper›PMID 37169112›Full record

ArticleFish & shellfish immunology2023

Isolation and characterization of single domain antibodies from banded houndshark (Triakis scyllium) targeting SARS-CoV-2 spike RBD protein.

Woo Sung Kim, Hee Do Chae, Inji Jung, Won-Kyu Lee, Woo Jun Lee, Jisun Lee, Yejin Gong, Dohyun Lee, Byeong-Won Kim, Jin-Koo Kim and 4 more

Open access · greenAbstract read
In one paragraph

Article in Fish & shellfish immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. VNAR development through antigen immunization of Japanese topeshark (Frontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Woo Sung KimDepartment of Pharmaceutical Engineering, Sangji University, Wonju, 26339, Republic of Korea.
Hee Do ChaeDepartment of Pharmaceutical Engineering, Sangji University, Wonju, 26339, Republic of Korea.
Inji JungDepartment of Biomedical Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
Won-Kyu LeeNew Drug Development Center, Osong Medical Innovation Foundation (Kbiohealth), Cheongju, 28160, Republic of Korea.
Woo Jun LeeDepartment of Marine Biology, Pukyong National University, Busan, 48513, Republic of Korea.
Jisun LeeDepartment of Biomedical Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
Yejin GongDepartment of Pharmaceutical Engineering, Sangji University, Wonju, 26339, Republic of Korea.
Dohyun LeeNew Drug Development Center, Osong Medical Innovation Foundation (Kbiohealth), Cheongju, 28160, Republic of Korea.
Byeong-Won KimNew Drug Development Center, Osong Medical Innovation Foundation (Kbiohealth), Cheongju, 28160, Republic of Korea.
Jin-Koo KimDepartment of Marine Biology, Pukyong National University, Busan, 48513, Republic of Korea.
Jaehyeon HwangDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Dae-Hyuk KweonDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Sang Taek JungDepartment of Biomedical Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, Republic of Korea. Electronic address: sjung@korea.ac.kr.
Jung-Hyun NaDepartment of Pharmaceutical Engineering, Sangji University, Wonju, 26339, Republic of Korea; Research Institute of Korean Medicine, Sangji University, Wonju, 26339, Republic of Korea. Electronic address: najunghyun@sangji.ac.kr.
Osong Medical Innovation Foundation · KRSangji University · KRKorea University · KRSungkyunkwan University · KRPukyong National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has significantly impacted human health for three years. To mitigate the spread of SARS-CoV-2, the development of neutralizing antibodies has been accelerated, including the exploration of alternative antibody formats such as single-domain antibodies. In this study, we identified variable new antigen receptors (VNARs) specific for the receptor binding domain (RBD) of SARS-CoV-2 by immunizing a banded houndshark (Triakis scyllium) with recombinant wild-type RBD. Notably, the CoV

Indexed as

COVID-19Single-Domain AntibodiesAnimalsAntibodies, NeutralizingAntibodies, ViralHumansPandemicsSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralSingle-Domain AntibodiesBanded houndshark (Triakis scyllium)COVID-19Phage display immune librarySARS-CoV-2Single domain antibodyVariable new antigen receptor (VNAR)

Identifiers

PMID37169112
PMCPMC10167778
OpenAlexW4375947873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.