ArticleInternational journal of particle therapy2023
Estimating Potential Benefits to Neurocognition with Proton Therapy in Adults with Brain Tumors.
Article in International journal of particle therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026Review
- Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).Radiation oncology (London, England) · 2026Article
- Bridging the proton gap: A proton therapy consultation service for Canadian radiation oncologists.Technical innovations & patient support in radiation oncology · 2025Article
- A review of proton beam therapy's role in glioma management.Medicine · 2025Review
- Current state of proton therapy for tumors of the central nervous system in Spain: physical bases, indications, controversies and perspectives.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Photon radiation therapy (RT) is important in the treatment of many brain tumors but can negatively affect neurocognition. Proton therapy (PT) can reduce doses to normal brain structures. We compared photon and proton plans to estimate the potential benefit in cognition if the patient were treated with PT. Materials and Methods: We analyzed 23 adult patients with proton and photon plans for the treatment of a primary brain tumor. Cognitive outcomes were predicted using converted equivalent dose (EQD2) with an α/β ratio of 3 to left temporal lobe and normal brain tissue. Risks of cognitive decline on 2 specific tests, the Controlled Oral Word Association Test (COWAT [letter S], a test of verbal fluency) and the Wechler Adult Intelligence Scale (WAIS-IV Coding Test, a test of processing speed) were derived from a previously published model. Results: Dose reductions to left temporal lobe and normal brain tissue translated into lower estimated probabilities of impairment in specific neurocognitive test scores after PT. With a mean dose reduction from 1490 to 1092 cGy in EQD2 to the left temporal lobe ( Conclusion: We confirmed an association between PT and lower doses to brain substructures, which is expected to result in a modest decrease in probability of impairment in neurocognitive test scoring. These findings should be confirmed in prospective cohorts of patients treated with PT.
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Registered trials
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