ArticleInternational journal of particle therapy2023
Characterization of 250 MeV Protons from the Varian ProBeam PBS System for FLASH Radiation Therapy.
Article in International journal of particle therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Neural Representation Learning for Compact and Efficient Modeling of Monte Carlo Phase Space Data.International journal of particle therapy · 2026Article
- Commissioning and Validation of a Synchrocyclotron - Based Ultra-High-Dose-Rate Beamline for FLASH.International journal of particle therapy · 2026Article
- Cell survival comparison of proton, helium, and carbon ion interlaced minibeams in water phantom simulations.Medical physics · 2026Article
- Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions.Scientific reports · 2026Article
- Beam commissioning of a new compact scanned proton therapy system with four different dose calculation algorithms.Journal of applied clinical medical physics · 2026Article
- Advancing Proton Therapy: Integration of Minibeam Spatial Fractionation and FLASH Dose Rates.Research square · 2025Article
- Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system.Medical physics · 2025Article
- Design and characterization of a novel scintillator array for UHDR PBS proton therapy surface dosimetry.Medical physics · 2025Article
- Characterization of commercial detectors for absolute proton UHDR dosimetry on a compact clinical proton synchrocyclotron.Medical physics · 2025Article
- Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality.International journal of radiation oncology, biology, physics · 2025Article
- Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?Frontiers in oncology · 2025Article
- A comprehensive pre-clinical treatment quality assurance program using unique spot patterns for proton pencil beam scanning FLASH radiotherapy.Journal of applied clinical medical physics · 2024Article
- Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research.Cancers · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shoot-through proton FLASH radiation therapy has been proposed where the highest energy is extracted from a cyclotron to maximize the dose rate (DR). Although our proton pencil beam scanning system can deliver 250 MeV (the highest energy), this energy is not used clinically, and as such, 250 MeV has yet to be characterized during clinical commissioning. We aim to characterize the 250-MeV proton beam from the Varian ProBeam system for FLASH and assess the usability of the clinical monitoring ionization chamber (MIC) for FLASH use. We measured the following data for beam commissioning: integral depth dose curve, spot sigma, and absolute dose. To evaluate the MIC, we measured output as a function of beam current. To characterize a 250 MeV FLASH beam, we measured (1) the central axis DR as a function of current and spot spacing and arrangement, (2) for a fixed spot spacing, the maximum field size that achieves FLASH DR (ie, > 40 Gy/s), and (3) DR reproducibility. All FLASH DR measurements were performed using an ion chamber for the absolute dose, and irradiation times were obtained from log files. We verified dose measurements using EBT-XD films and irradiation times using a fast, pixelated spectral detector. R90 and R80 from integral depth dose were 37.58 and 37.69 cm, and spot sigma at the isocenter were σ
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