Evidence map›Paper›PMID 37168963›Full record

ArticleCancer diagnosis & prognosis

The Usefulness of Total Laryngectomy in Sarcopenic Patients With Hypopharyngeal and Laryngeal Cancer.

Mutsukazu Kitano, Satoru Koike, Hisatomo Tamaki, Shusuke Iwamoto, Kazuhiro Miyamoto, Noriko Ohira, Takayuki Kimura, Mitsuo Sato, Ryuji Yasumatsu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Low Alanine Aminotransferase Blood Activity, a Biomarker of Sarcopenia and Frailty, is Associated With Worse Post-Total Laryngectomy Clinical Outcomes. A Retrospective Analysis of 427 Patients.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mutsukazu KitanoDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Satoru KoikeDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Hisatomo TamakiDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Shusuke IwamotoDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Kazuhiro MiyamotoDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Noriko OhiraDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Takayuki KimuraDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Mitsuo SatoDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Ryuji YasumatsuDepartment of Otolaryngology-Head and neck surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Kindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimSarcopenia has an adverse effect on postoperative complications and prognoses in head and neck cancer. This study focused on hypopharyngeal and laryngeal cancer patients with sarcopenia and analyzed the body composition following treatment when the larynx was preserved and when total laryngectomy was performed to examine the usefulness of laryngectomy. PATIENTS AND

methodsWe retrospectively reviewed 88 primary hypopharyngeal and laryngeal cancer patients aged 65 years or older with cT2N0M0 or higher who visited our department.

resultsThere were no significant differences in the 3-year overall survival rate and the 1-year local control rate between the laryngeal preservation group and laryngectomy group. The average change one year following treatment in the laryngeal preservation group, when compared to prior to treatment, was a significant decrease in the body weight (BW) of -0.035, skeletal muscle mass (SMM) of -0.030, skeletal muscle mass index (SMI) of -0.026, body mass index (BMI) of -0.034, and grip strength (GS) of -0.066. The average change one year following treatment in the laryngectomy group, compared with prior to treatment, was an increase in BW of +0.028, SMM of +0.026, SMI of +0.008, BMI of +0.032, and GS of +0.026. Although no changes in serum biochemical testing after treatment were observed in the laryngeal preservation group, albumin, transferrin, and transthyretin all exhibited significant improvement or a tendency toward improvement in the laryngectomy group. The patients with sarcopenia before treatment in the laryngeal preservation group had a significantly higher incidence of aspiration pneumonia.

conclusionThe presence or absence of sarcopenia before starting treatment is considered to be an index for selecting total laryngectomy.

Indexed as

hypopharyngeal cancerlaryngeal cancersarcopeniaTotal laryngectomy

Identifiers

PMID37168963
PMCPMC10165371
OpenAlexW4367677342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.