Evidence map›Paper›PMID 37168957›Full record

ReviewCancer diagnosis & prognosis

Calpain-mediated Mechanoptosis in Breast Adenocarcinoma.

Georgios I Metaxas, Despoina Spyropoulou, Sofianiki Mastronikoli, Evangelos Tsiambas, Evangelos Falidas, Spyridon Marinopoulos, Loukas Manaios, Dimitrios Davris, Panagiotis Fotiades, Dimitrios Peschos and 1 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

Georgios I MetaxasBreast Unit, 1st Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Despoina SpyropoulouDepartment of Radiation Oncology, Medical School, University of Patras, Patras, Greece.
Sofianiki MastronikoliBrighton and Sussex Medical School, Brighton, U.K.
Evangelos TsiambasDepartment of Cytology, 417 Veterans Army Hospital (NIMTS), Athens, Greece.
Evangelos FalidasDepartment of Surgery, Halkida General Hospital, Halkida, Greece.
Spyridon MarinopoulosBreast Unit, 1st Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Loukas ManaiosDepartment of Surgery, Bioclinic Medical Center, Athens, Greece.
Dimitrios DavrisDepartment of Surgery, Halkida General Hospital, Halkida, Greece.
Panagiotis FotiadesDepartment of Surgery, 424 Army Hospital, Thessaloniki, Greece.
Dimitrios PeschosDepartment of Physiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Constantine DimitrakakisBreast Unit, 1st Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Breast Center · CHGeneral Hospital of Attica · GR424 General Military Hospital · GRAlexandra Hospital · GRAthens Medical Center · GRBrighton and Sussex Medical School · GBInstitute of Cytology · RUUniversity of Ioannina · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calpains belong to a family of important calcium-dependent cysteine proteases. They are involved in intracellular processes including cytoskeleton disorganization and substrate proteolysis. They also enhance apoptosis and cell to cell adhesion. Calpains demonstrate also a mechanosensory function in neoplastic and malignant cells due to their implication in mechanoptosis. This is a specific type of apoptotic death induced by strong external mechanical stimuli. Anti-cytoskeleton rigidity inhibition strategies based on calpain induction lead to increased apoptosis of tumor transformed cells. Elevated intracellular calcium concentration mediated by specific receptors and channels activates calpains. In the current molecular review, we explored the role of calpains in calcium-dependent signa transduction pathways in breast adenocarcinoma in conjunction with novel agents that activate their important anti-tumor functions.

Indexed as

apoptosisbreast adenocarcinomaCalpainmechanoptosisreview

Identifiers

PMID37168957
PMCPMC10165377
OpenAlexW4367677387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.