Evidence map›Paper›PMID 37168859›Full record

ReviewFrontiers in immunology2023

Sebastian Joyce, Gosife Donald Okoye, John P Driver

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sebastian JoyceDepartment of Veterans Affairs, Tennessee Valley Healthcare Service, Nashville, TN, United States.
Gosife Donald OkoyeDepartment of Pathology, Microbiology and Immunology, The Vanderbilt Institute for Infection, Immunology and Inflammation and Vanderbilt Center for Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
John P DriverDivision of Animal Sciences, University of Missouri, Columbia, MO, United States.
Vanderbilt University Medical Center · USUniversity of Missouri · US

Funding

Genetically modified pigs to model NKT cell immunity to influenza virus infectionR01AI158477 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI John Driver, Juergen A Richt · 2022 to 2026
$3.2M
Harnessing Natural Killer T cells to counteract swine influenzaR01HD092286 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI DRIVER, JOHN · 2017 to 2021
$2.6M
Molecular Basis of CD1D and Natural Killer T Cell FunctionR01AI137082 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JOYCE, SEBASTIAN · 2019 to 2022
$2.1M
Vaccinating at Mucosal Surfaces with Nanoparticle Conjugated Antigen and AdjuvantI01BX001444 · VA · VETERANS HEALTH ADMINISTRATION · PI JOYCE, SEBASTIAN · 2014 to 2022
–
BLRD Research Career Scientist Award ApplicationIK6BX004595 · VA · VETERANS HEALTH ADMINISTRATION · PI JOYCE, SEBASTIAN · 2019 to 2025
–
BLRD VA I01 BX001444BLRD VA IK6 BX004595NIAID NIH HHS R01 AI137082NIAID NIH HHS R01 AI158477NICHD NIH HHS R01 HD092286
6 · The paper itself

Abstract

The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response. A multitudinous group of lymphoid lineage cells does not fit the conventional lymphocyte paradigm; it is the unconventional lymphocytes. Unconventional lymphocytes-here called innate/innate-like lymphocytes, include those that express rearranged antigen receptor genes and those that do not. Even though the innate/innate-like lymphocytes express rearranged, adaptive antigen-specific receptors, they behave like innate immune cells, which allows them to integrate sensory signals from the innate immune system and relay that umwelt to downstream innate and adaptive effector responses. Here, we review natural killer T cells and mucosal-associated invariant T cells-two prototypic innate-like T lymphocytes, which sense their local environment and relay that umwelt to downstream innate and adaptive effector cells to actuate an appropriate host response that confers immunity to infectious agents.

Indexed as

Mucosal-Associated Invariant T CellsNatural Killer T-CellsAdaptive ImmunityImmunity, InnateLymphocytesinnate-like effector lymphocyteMAIT (mucosal-associated invariant T) cellNKT (natural killer T) cellpathobiontsymbionts

Identifiers

PMID37168859
PMCPMC10165076
OpenAlexW4366828401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.