Evidence map›Paper›PMID 37168857›Full record

ArticleFrontiers in immunology2023

Commensal bacteria of the lung microbiota synergistically inhibit inflammation in a three-dimensional epithelial cell model.

Ellen Goeteyn, Lucia Grassi, Sara Van den Bossche, Charlotte Rigauts, Yannick Vande Weygaerde, Eva Van Braeckel, Tania Maes, Ken R Bracke, Aurélie Crabbé

Abstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Journal of bacteriology · 2026
    Review
  4. Article
  5. Article
  6. Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation.American journal of respiratory cell and molecular biology · 2026
    Article
  7. Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Recreating chronic respiratory infectionsEuropean respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ellen GoeteynLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Lucia GrassiLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Sara Van den BosscheLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Charlotte RigautsLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Yannick Vande WeygaerdeCystic Fibrosis Reference Centre, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Eva Van BraeckelCystic Fibrosis Reference Centre, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Tania MaesLung Research Lab, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Ken R BrackeLung Research Lab, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Aurélie CrabbéLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic lung disease suffer from persistent inflammation and are typically colonized by pro-inflammatory pathogenic bacteria. Besides these pathogens, a wide variety of commensal species is present in the lower airways but their role in inflammation is unclear. Here, we show that the lung microbiota contains several species able to inhibit activation of the pro-inflammatory NF-κB pathway and production of interleukin 8 (IL-8), triggered by lipopolysaccharide (LPS) or H

Indexed as

MicrobiotaPneumoniaAnti-Inflammatory AgentsBacteriaEpithelial CellsHumansHydrogen PeroxideInflammationInterleukin-8LungNF-kappa BAnti-Inflammatory AgentsHydrogen PeroxideInterleukin-8NF-kappa Bbeneficial commensalchronic lung disease (CLD)host-microbe interactioninflammationlung microbiome

Identifiers

PMID37168857
PMCPMC10164748

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.