ArticleJACC. Advances2023
Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population.
Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Cardiac Biomarkers and Pregnancy-Associated Cardiovascular Disease.Current cardiology reports · 2026Review
- BNP-Derived Uric Acid Composite Indices for the Evaluation of Dyspnea in Third-Trimester Pregnancy: A Prospective Emergency Department Study.Journal of clinical medicine · 2026Article
- NT-proBNP as a Predictive and Prognostic Biomarker for Complications in Hypertensive Pregnancy Disorders.Journal of clinical medicine · 2026Article
- Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2025Article
- Cardiac Biomarkers in Pregnancies With and Without Hypertension.American journal of hypertension · 2025Article
- An unexpected battle with peripartum cardiomyopathy: a case report.Future cardiology · 2025Article
- Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care.Circulation · 2025Review
- Artificial intelligence-based screening for cardiomyopathy in an obstetric population: A pilot study.Cardiovascular digital health journal · 2024Article
- Early-pregnancy N-terminal pro-brain natriuretic peptide level is inversely associated with hypertensive disorders of pregnancy diagnosed after 35 weeks of gestation.Scientific reports · 2024Article
- Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia.JAMA cardiology · 2024Article
- Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns.Biomedicines · 2023Article
- Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study.Cardiovascular diabetology · 2023Article
- NT-proBNP-Possible Prognostic Marker in Pregnant Patients with Associated Cardiovascular Risk Factors and SARS-CoV-2 Infection.Diagnostics (Basel, Switzerland) · 2023Article
- Pregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health.Circulation research · 2023Review
- Dynamics of NT-proBNP in Pregnancy: Why Values May Be Elevated in the First Trimester.JACC. Advances · 2023Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPhysiologic changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) across trimesters of pregnancy have not been well studied.
objectivesThe authors aimed to measure NT-proBNP in adult women, by pregnancy status and trimester, in a nationally representative sample from the National Health and Nutrition Examination Survey 1999 to 2004.
methodsWe conducted a cross-sectional analysis of 2,134 women (546 pregnant) aged 20 to 40 years without a history of cardiovascular disease.
resultsAmong pregnant women in the first trimester, the prevalence of elevated NT-proBNP (>125 pg/mL) was 20.0% (SE, 6.6%) compared to 2.4% (SE, 0.8%) among women in the third trimester and 8.0% among nonpregnant women. After adjustment for demographics and cardiovascular risk factors, NT-proBNP was 44% higher (absolute difference 26.4 [95% CI: 11.2-41.6] pg/mL) in the first trimester of pregnancy compared to nonpregnant women. Among pregnant women only, adjusted NT-proBNP was 46% lower (absolute difference -22.2 [95% CI: -36.9 to -7.5] pg/mL) in women in the third trimester compared to women in the first trimester. NT-proBNP was inversely associated with body mass index and with systolic blood pressure.
conclusionsWomen in the first trimester of pregnancy had significantly higher NT-proBNP than those in the third trimester and compared to similarly aged nonpregnant women. The dynamic nature of NT-proBNP should be taken into consideration when ordering NT-proBNP lab tests in pregnant women.
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