Evidence map›Paper›PMID 37168577›Full record

ArticleiScience2023

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.

Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chenyang LuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Jinglin ZhangInstitute of Reproduction and Metabolism, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Bingjie WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Qiao GaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Kezhe MaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Shaona PeiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Juxue LiState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Sheng CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, People's Republic of China.
Yangzhou University · CNJiangsu Provincial Center for Disease Control and Prevention · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear. Casein kinase 1α (CK1α) was expressed in the embryonic mouse hypothalamus at high levels and colocalized with POMC neurons. CK1α deletion in POMC neurons caused weight gain, metabolic defects, and increased food intake. The number of POMC-expressing cells was considerably decreased in Csnk1a1

Indexed as

Cellular neuroscienceDevelopmental neuroscienceNeuroscience

Identifiers

PMID37168577
PMCPMC10165255
OpenAlexW4365517457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.