Evidence map›Paper›PMID 37168492›Full record

ArticleFunction (Oxford, England)2023

Oxidation Driven Reversal of PIP

Sun-Joo Lee, Shoji Maeda, Jian Gao, Colin G Nichols

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. [Exogenous nitric oxide suppresses KSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Redox Bridling of GIRK Channel Activity.Function (Oxford, England) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sun-Joo LeeDepartment of Cell Biology and Physiology and the Center for Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6302-7986
Shoji MaedaDepartment of Pharmacology, Medical School, University of Michigan, Ann Arbor, Michigan, USA.
Jian GaoDepartment of Cell Biology and Physiology and the Center for Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Colin G NicholsDepartment of Cell Biology and Physiology and the Center for Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-4929-2134
Washington University in St. Louis · USUniversity of Michigan · US

Funding

Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaR35HL140024 · NHLBI · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2018 to 2023
$5.9M
Structure/function analysis of understudied pH-sensitive Kir4.2 channels in vitro with conformation specific nanobodiesR03TR003670 · NCATS · WASHINGTON UNIVERSITY · PI LEE, SUN JOO · 2021 to 2021
$158k
NCATS NIH HHS R03 TR003670NHLBI NIH HHS R35 HL140024
6 · The paper itself

Abstract

Physiological activity of G protein gated inward rectifier K

Indexed as

G Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsLigandsOxidation-ReductionG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsKCNJ6 protein, humanLigandsGIRK2kir3oxidationoxidative stressPIP2reversed gating

Identifiers

PMID37168492
PMCPMC10165546
OpenAlexW4363679154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.