Evidence map›Paper›PMID 37168340›Full record

ArticleAmerican journal of cancer research2023

Guanylate binding protein 5 accelerates gastric cancer progression via the

Feng-Yu Cao, Chen-Hong Wang, Xiang Li, Ming-Zhen Ma, Gong-Cai Tao, Chao Yang, Kai Li, Xiao-Bo He, Shi-Lun Tong, Qing-Chuan Zhao and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Multifaceted Roles of Guanylate-Binding Proteins in Cancer.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Inflammatory factors collaboratively linkFrontiers in immunology · 2025
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Feng-Yu CaoDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Chen-Hong WangDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Xiang LiDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Ming-Zhen MaDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Gong-Cai TaoDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Chao YangDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Kai LiDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Xiao-Bo HeDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Shi-Lun TongDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Qing-Chuan ZhaoState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University Xi'an 710032, Shaanxi, China.
Song SuDepartment of Gastroenterology, The First Medical Center of Chinese PLA General Hospital Beijing 100853, China.
Dan SongDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Yong-Bin ZhengDepartment of Gastrointestinal Surgery, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University Wuhan 430000, Hubei, China.
Wuhan University · CNChinese PLA General Hospital · CNXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanylate binding protein 5 (GBP5) is a member of the interferon (IFN)-inducible large guanosine triphosphate hydrolases (GTPase) family that regulates cell-autonomous immunity and malignant tumor transformation. However, its specific roles and underlying mechanisms GBP5 in gastric cancer (GC) remain unknown. In this study, we aimed to determine the role GBP5 and underlying mechanism of

Indexed as

CXCL8Gastric cancerGBP5IFNγ-JAK1-STAT1 signalingpositive feedback loop

Identifiers

PMID37168340
PMCPMC10164808
OpenAlexW4376226118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.