ArticleFrontiers in microbiology2023
Two-sample Mendelian randomization analysis investigates causal associations between gut microbiota and attention deficit hyperactivity disorder.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Gut Microbiota Composition and Diversity in Attention-Deficit/Hyperactivity Disorder: A Systematic Review.Microorganisms · 2026Review
- Causal Effects of Yogurt Intake on Gut Microbiota: A European Mendelian Randomization Study.International journal of genomics · 2026Article
- Methylphenidate and Its Impact on Redox Balance and Behavior.Journal of xenobiotics · 2025Review
- Disruption of gut microbiome and metabolome in treatment-naïve children with attention deficit hyperactivity disorder.BMC microbiology · 2025Article
- The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder.Journal of biomedical science · 2025Review
- Exploring the Relationship Between Sporadic Creutzfeldt-Jakob Disease and Gut Microbiota Through a Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Causal Relationship Between Sjögren's Syndrome and Gut Microbiota: A Two-Sample Mendelian Randomization Study.Biomedicines · 2024Article
- MICROBIOME: The trials and errors of developing an experimental model to study the impact of maternal gut microbiome disruption on perinatal asphyxia.Reproduction & fertility · 2024Article
- Multikingdom and functional gut microbiota markers for autism spectrum disorder.Nature microbiology · 2024Article
- Harnessing the Gut Microbiome: To What Extent Can Pre-/Probiotics Alleviate Immune Activation in Autism Spectrum Disorder?Nutrients · 2024Review
- Gut Microbiota and Clinical Manifestations in Thai Pediatric Patients with Attention-Deficit Hyperactivity Disorder.Journal of personalized medicine · 2024Article
- Causal associations between gut microbiota and synovitis-tenosynovitis: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota.Frontiers in microbiology · 2024Article
- Casual effects of type 1 diabetes mellitus on site-specific digestive cancers: a Mendelian randomisation analysis.Frontiers in endocrinology · 2024Article
- The Gut-Liver-Brain Axis: From the Head to the Feet.International journal of molecular sciences · 2023Article
- Association of Gut-Microbiome and mental health and effects of probiotics on psychiatric disorders: A Meta-analysis and systematic review.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research has suggested a link between gut microbiota and attention deficit hyperactivity disorder (ADHD), but their causal relationship has not been elucidated. Aiming to comprehensively investigate their causal relationship and to identify specific causal microbe taxa for ADHD, we conducted a two-sample Mendelian randomization (MR) analysis. Instrumental variables of 211 gut microbiota taxa were obtained from gene wide association study (GWAS), and Mendelian randomization study was carried out to estimate their effects on ADHD risk from PGC GWAS (20,183 ADHD cases and 35,191 controls) and FinnGen GWAS (830 ADHD cases and 215,763 controls). Wald ratio (WR), inverse variance weighted (IVW), MR-Egger, and weighted median were the main methods to analyze causality, and MR results are verified by several sensitivity analysis analyses. At locus-wide significance level (
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