Evidence map›Paper›PMID 37167382›Full record

ArticleScience (New York, N.Y.)2023

Demographic history and genetic structure in pre-Hispanic Central Mexico.

Viridiana Villa-Islas, Alan Izarraras-Gomez, Maximilian Larena, Elizabeth Mejía Perez Campos, Marcela Sandoval-Velasco, Juan Esteban Rodríguez-Rodríguez, Miriam Bravo-Lopez, Barbara Moguel, Rosa Fregel, Ernesto Garfias-Morales and 17 more

Abstract readHistorical Article
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  5. Genetic and genomic insights of the Comcáac people.Journal of community genetics · 2025
    Review
  6. A reanalysis of population dynamics in the Casas Grandes region of Northern Mexico using mitochondrial DNA.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Viridiana Villa-IslasInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0001-9218-561X
Alan Izarraras-GomezInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0002-2992-670X
Maximilian LarenaDepartment of Organismal Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8799-7645
Elizabeth Mejía Perez CamposNational Institute of Anthropology and History, Querétaro, Mexico.
Marcela Sandoval-VelascoSection for Evolutionary Genomics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4635-6171
Juan Esteban Rodríguez-RodríguezInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0003-4706-2201
Miriam Bravo-LopezInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0002-9627-617X
Barbara MoguelInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0002-4489-0055
Rosa FregelDepartment of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.ORCID 0000-0002-2951-6508
Ernesto Garfias-MoralesInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0001-9469-7555
Jazeps Medina TretmanisCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-4589-025X
David Alberto Velázquez-RamírezInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-7893-8467
Alberto Herrera-MuñózNational Institute of Anthropology and History, Querétaro, Mexico.ORCID 0000-0002-8971-7678
Karla SandovalEquity and Gender Office of the Centre for Research and Advanced Studies (CODIGO-C), CINVESTAV, Mexico City, Mexico.
Maria A Nieves-ColónUnit of Advanced Genomics, National Laboratory of Genomics for Biodiversity (LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico.ORCID 0000-0001-9035-6091
Gabriela Zepeda García MorenoNational Institute of Anthropology and History, Guanajuato, Mexico.
Fernando A VillaneaDepartment of Anthropology, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-6661-0368
Eugenia Fernández Villanueva MedinaNational Institute of Anthropology and History, Michoacán, Mexico.ORCID 0000-0001-6969-5769
Ramiro Aguayo-HaroNational Institute of Anthropology and History, Michoacán, Mexico.
Cristina ValdioseraDepartamento de Historia, Geografía y Comunicaciones, Universidad de Burgos, Burgos, Spain.ORCID 0000-0003-4948-2226
Alexander G IoannidisInstitute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4735-7803
Andrés Moreno-EstradaUnit of Advanced Genomics, National Laboratory of Genomics for Biodiversity (LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico.ORCID 0000-0001-8329-8292
Flora JayLaboratoire Interdisciplinaire des Sciences du Numérique, Université Paris-Saclay, CNRS, INRIA, 91400 Orsay, France.ORCID 0000-0001-5884-4730
Emilia Huerta-SanchezCenter for Computational Molecular Biology, Brown University, Providence, RI, USA.ORCID 0000-0002-1506-5494
J Víctor Moreno-MayarLundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7712-4496
Federico Sánchez-QuintoComputational Genomics, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico.ORCID 0000-0002-0201-6204
María C Ávila-ArcosInternational Laboratory for Human Genome Research, Universidad Nacional Autónoma de México (UNAM), Querétaro, México.ORCID 0000-0003-1691-1696

Funding

Characterizing modes of natural selection via diverse ancient and modern samplesR35GM128946 · NIGMS · BROWN UNIVERSITY · PI Emilia Huerta-Sanchez · 2018 to 2026
$3.1M
NIGMS NIH HHS R35 GM128946Wellcome Trust
6 · The paper itself

Abstract

Aridoamerica and Mesoamerica are two distinct cultural areas in northern and central Mexico, respectively, that hosted numerous pre-Hispanic civilizations between 2500 BCE and 1521 CE. The division between these regions shifted southward because of severe droughts ~1100 years ago, which allegedly drove a population replacement in central Mexico by Aridoamerican peoples. In this study, we present shotgun genome-wide data from 12 individuals and 27 mitochondrial genomes from eight pre-Hispanic archaeological sites across Mexico, including two at the shifting border of Aridoamerica and Mesoamerica. We find population continuity that spans the climate change episode and a broad preservation of the genetic structure across present-day Mexico for the past 2300 years. Lastly, we identify a contribution to pre-Hispanic populations of northern and central Mexico from two ancient unsampled "ghost" populations.

Indexed as

Genetic StructuresHispanic or LatinoHistory, AncientHumansMexicoPopulation Dynamics

Identifiers

PMID37167382
PMCPMC12087575

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.