Evidence map›Paper›PMID 37167266›Full record

ArticleACS applied materials & interfaces2023

KR-12 Derivatives Endow Nanocellulose with Antibacterial and Anti-Inflammatory Properties: Role of Conjugation Chemistry.

Anna Blasi-Romero, Molly Ångström, Antonio Franconetti, Taj Muhammad, Jesús Jiménez-Barbero, Ulf Göransson, Carlos Palo-Nieto, Natalia Ferraz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anna Blasi-RomeroDivision of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. Box 35, SE-75103 Uppsala, Sweden.
Molly ÅngströmDivision of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. Box 35, SE-75103 Uppsala, Sweden.
Antonio FranconettiCIC bioGUNE, Derio-Bizkaia 48160, Spain.ORCID 0000-0002-7972-8795
Taj MuhammadPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, P.O. Box 591, SE-75124 Uppsala, Sweden.
Jesús Jiménez-BarberoCIC bioGUNE, Derio-Bizkaia 48160, Spain.ORCID 0000-0001-5421-8513
Ulf GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, P.O. Box 591, SE-75124 Uppsala, Sweden.ORCID 0000-0002-5005-9612
Carlos Palo-NietoDivision of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. Box 35, SE-75103 Uppsala, Sweden.
Natalia FerrazDivision of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. Box 35, SE-75103 Uppsala, Sweden.ORCID 0000-0002-0202-2401
Uppsala University · SECIC bioGUNE · ESIkerbasque · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work combines the wound-healing-related properties of the host defense peptide KR-12 with wood-derived cellulose nanofibrils (CNFs) to obtain bioactive materials, foreseen as a promising solution to treat chronic wounds. Amine coupling through carbodiimide chemistry, thiol-ene click chemistry, and Cu(I)-catalyzed azide-alkyne cycloaddition were investigated as methods to covalently immobilize KR-12 derivatives onto CNFs. The effects of different coupling chemistries on the bioactivity of the KR12-CNF conjugates were evaluated by assessing their antibacterial activities against

Indexed as

Anti-Bacterial AgentsEscherichia coliAntimicrobial Cationic PeptidesChemical PhenomenaStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial Cationic Peptidesantimicrobial peptidescellulose nanofibrilschronic woundsmolecular dynamics simulationspeptide immobilizationwound healing

Identifiers

PMID37167266
PMCPMC10214380
OpenAlexW4376224872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.