Evidence map›Paper›PMID 37167085›Full record

ReviewThe Journal of general virology2023

Plasma after both SARS-CoV-2 boosted vaccination and COVID-19 potently neutralizes BQ.1.1 and XBB.1.

David J Sullivan, Massimo Franchini, Jonathon W Senefeld, Michael J Joyner, Arturo Casadevall, Daniele Focosi

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of general virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  8. Article
  9. Guidance on the Use of Convalescent Plasma to Treat Immunocompromised Patients With Coronavirus Disease 2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
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  18. Genomic surveillance of SARS-CoV-2 positive passengers on flights from China to Italy, December 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

David J SullivanJohns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, MD 21218, USA.
Massimo FranchiniDivision of Transfusion Medicine, Carlo Poma Hospital, 46100 Mantua, Italy.
Jonathon W SenefeldDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, MN 55902, USA.
Michael J JoynerDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, MN 55902, USA.
Arturo CasadevallJohns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, MD 21218, USA.
Daniele FocosiNorth-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.
Johns Hopkins University · USMayo Clinic · USAzienda Ospedaliera Carlo Poma · IT

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Johns Hopkins-Tufts Trial Innovation Center HEAL Pain ERN SupplementU24TR001609 · NCATS · JOHNS HOPKINS UNIVERSITY · PI HANLEY, DANIEL F · 2016 to 2022
$36.3M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
NCATS NIH HHS U24 TR001609NCATS NIH HHS UL1 TR003098NIAID NIH HHS R01 AI152078
6 · The paper itself

Abstract

Recent 2022 SARS-CoV-2 Omicron variants, have acquired resistance to most neutralizing anti-Spike monoclonal antibodies authorized, and the BQ.1.* sublineages are notably resistant to all authorized monoclonal antibodies. Polyclonal antibodies from individuals both vaccinated and recently recovered from Omicron COVID-19 (VaxCCP) could retain new Omicron neutralizing activity. Here we reviewed BQ.1.* virus neutralization data from 920 individual patient samples from 43 separate cohorts defined by boosted vaccinations (Vax) with or without recent Omicron COVID-19, as well as infection without vaccination (CCP) to determine level of BQ.1.* neutralizing antibodies and percent of plasma samples with neutralizing activity. More than 90 % of the plasma samples from individuals in the recently (within 6 months) boosted VaxCCP study cohorts neutralized BQ.1.1, and BF.7 with 100 % neutralization of WA-1, BA.4/5, BA.4.6 and BA.2.75. The geometric mean of the geometric mean 50 % neutralizing titres (GM (GMT

Indexed as

COVID-19SARS-CoV-2Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralHumansVaccinationAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBF.7: virus neutralizationBQ.1.1convalescent plasmaCOVID-19SARS-CoV-2XBB

Identifiers

PMID37167085
PMCPMC10336427
OpenAlexW4376134504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.