Evidence map›Paper›PMID 37167070›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Gold-Catalyzed Amine Cascade Addition to Diyne-Ene: Enantioselective Synthesis of 1,2-Dihydropyridines.

Jingwen Wei, Yangyang Xing, Xiaohan Ye, Bao Nguyen, Lukasz Wojtas, Xin Hong, Xiaodong Shi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jingwen WeiDepartment of Chemistry, University of South Florida, FL 33620, Tampa, USA.
Yangyang XingCenter of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China.
Xiaohan YeDepartment of Chemistry, University of South Florida, FL 33620, Tampa, USA.
Bao NguyenDepartment of Chemistry, University of South Florida, FL 33620, Tampa, USA.
Lukasz WojtasDepartment of Chemistry, University of South Florida, FL 33620, Tampa, USA.
Xin HongCenter of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, 310027, Hangzhou, China.
Xiaodong ShiDepartment of Chemistry, University of South Florida, FL 33620, Tampa, USA.ORCID http://orcid.org/0000-0002-3189-1315
University of South Florida · USZhejiang University · CN

Funding

Achieving challenging coupling with gold redox catalysisR01GM120240 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI SHI, XIAODONG · 2016 to 2020
$1.6M
Developing Asymmetric Gold Redox Catalysis for Challenging Chemical TransformationsR01GM147135 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI SHI, XIAODONG · 2022 to 2025
$1.3M
NIGMS NIH HHS R01 GM120240NIGMS NIH HHS R01 GM147135NIH HHS 1R01GM120240-01
6 · The paper itself

Abstract

With the well-documented chemical and biological applications, piperidine and pyridine are among the most important N-heterocycles, and a new synthetic strategy, especially one with an alternative bond-forming design, is of general interest. Using the gold-catalyzed intermolecular condensation of amine and diyne-ene, we report herein the first example of enantioselective 1,2-dihydropyridine synthesis through a formal [3+2+1] fashion (up to 95 % yield, up to 99 % e.e.).

Indexed as

DihydropyridineDiyne-EneEnantioselectiveGold Catalysis

Identifiers

PMID37167070
PMCPMC10524696
OpenAlexW4376135127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.