Evidence map›Paper›PMID 37167061›Full record

ArticleCell reports2023

Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus.

Teruaki Nakatsuji, Samantha L Brinton, Kellen J Cavagnero, Alan M O'Neill, Yang Chen, Tatsuya Dokoshi, Anna M Butcher, Olive C Osuoji, Faiza Shafiq, Josh L Espinoza and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Fibroblasts resistScience advances · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Host-Microbiome Interactions in Chronic Itch.Journal of clinical medicine · 2025
    Review
  13. Article
  14. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Antimicrobial Peptide Signaling in Skin Diseases.JID innovations : skin science from molecules to population health · 2025
    Review
  16. Article
  17. Article
  18. Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Teruaki NakatsujiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Samantha L BrintonDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Kellen J CavagneroDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Alan M O'NeillDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Yang ChenDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Tatsuya DokoshiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Anna M ButcherDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Olive C OsuojiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Faiza ShafiqDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Josh L EspinozaGenomic Medicine, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Christopher L DupontGenomic Medicine, J. Craig Venter Institute, La Jolla, CA 92037, USA.
Tissa R HataDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: rgallo@health.ucsd.edu.
University of California San Diego · USJ. Craig Venter Institute · USUC San Diego Health System · US

Funding

Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Microbiome Function in Atopic DermatitisU01AI152038 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo · 2020 to 2026
$3.3M
Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Inflammatory cross-talk between skin and gutR01DK128787 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, SALZMAN, NITA H · 2021 to 2024
$2.6M
Conflict and Cooperation between AMP Species on the skinR01AR076082 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2019 to 2023
$2.3M
NIAID NIH HHS R01 AI153185NIAID NIH HHS R37 AI052453NIAID NIH HHS U01 AI152038NIAMS NIH HHS R01 AR076082NIDDK NIH HHS R01 DK128787
6 · The paper itself

Abstract

During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic inflammation it becomes more susceptible to Staphylococcus aureus. To understand this contradiction, single-cell sequencing of Il4ra

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsAntimicrobial PeptidesBacteriaHumansInflammationMiceSkinStaphylococcusStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial Peptidesatopic dermatitisbacteriocincathelicidincoagulase negative StaphylococcusCP: ImmunologyCP: MicrobiologyCrampinfectionInterleukin-4 receptor alphalantibioticStaphylococcus hominis

Identifiers

PMID37167061
PMCPMC10303920
OpenAlexW4376224591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.