Evidence map›Paper›PMID 37166640›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Assembly of the Mitochondrial Translation Initiation Complex.

Cristina Remes, Minh Duc Nguyen, Henrik Spahr, Martin Ng, Clark Fritsch, Arpan Bhattacharya, Hong Li, Barry Cooperman, Joanna Rorbach

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cristina RemesDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA. cremes@sas.upenn.edu.
Minh Duc NguyenDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
Henrik SpahrDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
Martin NgDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Clark FritschDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Arpan BhattacharyaDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Hong LiDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Barry CoopermanDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Joanna RorbachDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
University of Pennsylvania · USKarolinska Institutet · SEPhiladelphia University · US

Funding

Mechanisms of Induced Nonsense Suppression and MisreadingR01GM127374 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARRY S. COOPERMAN · 2018 to 2026
$2.3M
NIGMS NIH HHS R01 GM127374
6 · The paper itself

Abstract

Mitochondria maintain their own translational machinery that is responsible for the synthesis of essential components of the oxidative phosphorylation system. The mammalian mitochondrial translation system differs significantly from its cytosolic and bacterial counterparts. Here, we describe detailed protocols for efficient in vitro reconstitution of the mammalian mitochondrial translation initiation complex, which can be further used for mechanistic analyses of different aspects of mitochondrial translation.

Indexed as

MitochondriaProtein BiosynthesisAnimalsCytosolMammalsMitochondrial ProteinsMitochondrial RibosomesOxidative PhosphorylationProtein Processing, Post-TranslationalMitochondrial ProteinsMitoribosomeTranslationTranslation factorsTranslation initiationtRNA purification

Identifiers

PMID37166640
OpenAlexW4376132648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.