Evidence map›Paper›PMID 37166629›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Evolution: Mitochondrial Ribosomes Across Species.

Rajendra K Agrawal, Soneya Majumdar

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rajendra K AgrawalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health Empire State Plaza, Albany, NY, USA. rajendra.agrawal@health.ny.gov.
Soneya MajumdarDivision of Translational Medicine, Wadsworth Center, New York State Department of Health Empire State Plaza, Albany, NY, USA.

Funding

Structural Aspects of Protein Synthesis in the Mammalian MitochondriaR01GM061576 · NIGMS · WADSWORTH CENTER · PI AGRAWAL, RAJENDRA K · 2001 to 2018
$6.4M
Alternative Ribosomes & Antibiotic Tolerance in MycobacteriaR01AI132422 · NIAID · WADSWORTH CENTER · PI RAJENDRA K AGRAWAL, Anil Kumar Ojha · 2017 to 2026
$3.8M
Role of ribosome modulating proteins in conferring Mycobacterium abscessus antibiotic resistanceR01AI155473 · NIAID · WADSWORTH CENTER · PI GHOSH, PALLAVI · 2020 to 2024
$2.4M
Systematic Discovery and Analysis of Small Proteins and Small ORFs in MycobacteriaR01GM139277 · NIGMS · WADSWORTH CENTER · PI DERBYSHIRE, KEITH M, GRAY, TODD · 2020 to 2023
$2.2M
NIAID NIH HHS R01 AI132422NIAID NIH HHS R01 AI155473NIGMS NIH HHS R01 GM061576NIGMS NIH HHS R01 GM139277
6 · The paper itself

Abstract

The ribosome is among the most complex and ancient cellular macromolecular assemblies that plays a central role in protein biosynthesis in all living cells. Its function of translation of genetic information encoded in messenger RNA into protein molecules also extends to subcellular compartments in eukaryotic cells such as apicoplasts, chloroplasts, and mitochondria. The origin of mitochondria is primarily attributed to an early endosymbiotic event between an alpha-proteobacterium and a primitive (archaeal) eukaryotic cell. The timeline of mitochondrial acquisition, the nature of the host, and their diversification have been studied in great detail and are continually being revised as more genomic and structural data emerge. Recent advancements in high-resolution cryo-EM structure determination have provided architectural details of mitochondrial ribosomes (mitoribosomes) from various species, revealing unprecedented diversifications among them. These structures provide novel insights into the evolution of mitoribosomal structure and function. Here, we present a brief overview of the existing mitoribosomal structures in the context of the eukaryotic evolution tree showing their diversification from their last common ancestor.

Indexed as

MitochondriaMitochondrial RibosomesCryoelectron MicroscopyEukaryotaEukaryotic CellsMitochondrial ProteinsRibosomal ProteinsRibosomesMitochondrial ProteinsRibosomal ProteinsCryo-EM structuresEvolutionMitochondrial ribosomesMitochondrial rRNAsMRPs

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.