Evidence map›Paper›PMID 37166517›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2023

Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression.

Andrea D Kim, Lin Kui, Benedikt Kaufmann, Sung Eun Kim, Aleksandra Leszczynska, Ariel E Feldstein

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. [Research progress on serum chitinase-3-like protein 1 for diagnosing early-stage liver fibrosis non-invasively].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Andrea D Kim *Department of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA.
Lin Kui *Department of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA.
Benedikt KaufmannDepartment of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA.
Sung Eun KimDepartment of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA.
Aleksandra LeszczynskaDepartment of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA.
Ariel E FeldsteinDepartment of Pediatrics, University of California San Diego, 3020 Children's Way, MC 5030, La Jolla, San Diego, CA, 92103-8450, USA. afeldstein@ucsd.edu.ORCID http://orcid.org/0000-0001-7202-3840
University of California San Diego · USHallym University · KRTUM Klinikum · DE

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Sterile inflammation and pyroptotic cell death in liver fibrosisR01DK113592 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariel Feldstein, HAROLD M HOFFMAN · 2017 to 2026
$4.8M
Gain of function mutations in inflammasome related genes in human and experimental alcoholic liver diseaseR01AA024206 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL · 2019 to 2021
$988k
NCATS NIH HHS UL1 TR001442NIAAA NIH HHS R01 AA024206NIDDK NIH HHS R01 DK113592NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Chitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic liver diseases including non-alcoholic steatohepatitis (NASH). However, the mechanisms by which CHI3L1 contributes to fibrogenesis remain undefined. Here, we showed that infiltrating monocyte-derived liver macrophages represent the main source of CHI3L1 in murine NASH. We developed a floxed CHI3L1 knock-out (KO) mouse to further study the cell-specific role of CHI3L1 ablation. Wildtype (WT) and myeloid cell-specific CHI3L1 KO mice (Cre

Indexed as

ChitinasesInterleukin-13 Receptor alpha2 SubunitNon-alcoholic Fatty Liver DiseaseAcetamidesAnimalsDiet, High-FatDisease Models, AnimalHumansLiverLiver CirrhosisMiceMice, Inbred C57BLMice, KnockoutAcetamidesCDAAChitinasesInterleukin-13 Receptor alpha2 SubunitChitinase-like proteinsHepatic stellate cellsInfiltrating macrophagesNon-alcoholic fatty liver disease

Identifiers

PMID37166517
PMCPMC10300183
OpenAlexW4376133747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.