Evidence map›Paper›PMID 37166463›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2023

Advancement in nanotechnology for treatment of rheumatoid arthritis: scope and potential applications.

Radha Rani, Neha Raina, Ajay Sharma, Pramod Kumar, Hardeep Singh Tulli, Madhu Gupta

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Radha RaniDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Neha RainaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Ajay SharmaInstitute of Nuclear Medicine & Allied Sciences (INMAS-DRDO), Ministry of Defence, Brig. SK Mazumdar Marg, Lucknow Road, Timarpur, Delhi-110054, India.
Pramod KumarInstitute of Lung Health and Immunity, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Hardeep Singh TulliDepartment of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, 133207, India.
Madhu GuptaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India. madhugupta98@gmail.com.ORCID http://orcid.org/0000-0002-8503-0609
Delhi Pharmaceutical Science and Research University · INHelmholtz Zentrum München · DEInstitute of Nuclear Medicine & Allied Sciences · INMaharishi Markandeshwar University, Mullana · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis is a hyperactive immune disorder that results in severe inflammation in synovial joints, cartilage, and bone deterioration, resulting in immobilization of joints. Traditional approaches for the treatment of rheumatoid arthritis are associated with some limiting factors such as suboptimal patient compliance, inability to control the progression of disorder, and safety concerns. Therefore, innovative drug delivery carriers for efficient therapeutic delivery at inflamed synovial sites with better safety assessment are urgently needed to address these issues. From this perspective, nanotechnology is an outstanding alternative to traditional drug delivery approaches, and it has shown great promise in developing novel carriers to treat rheumatoid arthritis. Considering the current research and future application of nanocarriers, it is believed that nanocarriers can be a crucial element in rheumatoid arthritis treatment. This paper covers all currently available pathophysiological aspects of rheumatoid arthritis and treatment options. Future research for the reduction of synovial inflammation should focus on developing multifunction nanoparticles capable of delivering therapeutic agents with improved safety, efficacy, and cost-effectiveness to be commercialized.

Indexed as

Arthritis, RheumatoidNanoparticlesDrug CarriersDrug Delivery SystemsHumansInflammationNanotechnologyDrug CarriersAnimal modelsBiological agentsNanocarriersNanotechnologyRheumatoid arthritisTargeted therapy

Identifiers

PMID37166463
OpenAlexW4376132966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.