Evidence map›Paper›PMID 37166035›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Cancer Nanobombs Delivering Artoxplatin with a Polyigniter Bearing Hydrophobic Ferrocene Units Upregulate PD-L1 Expression and Stimulate Stronger Anticancer Immunity.

Yongchao Gao, Hanchen Zhang, Lin Tang, Feifei Li, Li Yang, Haihua Xiao, Johannes Karges, Weihua Huang, Wei Zhang, Chaoyong Liu

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  4. Endogenous FeAnimal models and experimental medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Yongchao GaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China.ORCID 0000-0002-1631-7390
Hanchen ZhangBeijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Physics and Chemistry and CAS Key Laboratories of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Lin TangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Feifei LiBeijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Li YangInstitute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, 999078, P. R. China.
Haihua XiaoBeijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Physics and Chemistry and CAS Key Laboratories of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Johannes KargesFaculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany.
Weihua HuangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China.
Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China.ORCID 0000-0002-6190-3129
Chaoyong LiuBeijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.ORCID 0000-0002-0914-687X
Beijing University of Chemical Technology · CNCentral South University · CNChinese Academy of Sciences · CNRuhr University Bochum · DEUniversity of Macau · MO

Funding

National Key Research and Development Program of China 2021YFA1301200National Natural Science Foundation of China 52073015National Natural Science Foundation of China 81874329National Natural Science Foundation of China 82073945Project Program of National Clinical Research Center for Geriatric Disorders 2020LNJJ06
6 · The paper itself

Abstract

Poor immunogenicity seriously hampers the broader implementation of antitumor immunotherapy. Enhanced immunogenicity capable of achieving greater antitumor immunity is urgently required. Here, a novel polymer that contains hydrophobic ferrocene (Fc) units and thioketal bonds in the main chain, which further delivered a prodrug of oxaliplatin and artesunate, i.e., Artoxplatin, to cancer cells is described. This polymer with Fc units in the nanoparticle can work as a polyigniter to spark the peroxide bonds in Artoxplatin and generate abundant reactive oxygen species (ROS) to kill cancers as nanobomb

Indexed as

B7-H1 AntigenFerrous CompoundsNeoplasmsHumansMetallocenesPolymersReactive Oxygen SpeciesB7-H1 AntigenferroceneFerrous CompoundsMetallocenesPolymersReactive Oxygen Speciesartoxplatinchemo-immunotherapyimmunogenic cell deathoxaliplatinreactive oxygen species

Identifiers

PMID37166035
PMCPMC10811492
OpenAlexW4376133622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.