Evidence map›Paper›PMID 37165726›Full record

ArticleJournal of cellular and molecular medicine2023

EGFR marks a subpopulation of dermal mesenchymal cells highly expressing IGF1 which enhances hair follicle regeneration.

Min Chen, Zaoxu Xu, Yu Chen, Qingyang Yang, Ruiqing Lu, Yankai Dong, Xiaosong Li, Jundong Xie, Ren-He Xu, Haidong Jia and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Generation of theInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Min ChenTsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China.ORCID 0000-0003-0521-7172
Zaoxu XuCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Yu ChenState Key Laboratory of Chemical Oncogenomics, and the Institute of Biopharmaceutical and Health Engineering (iBHE), Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Qingyang YangTsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China.
Ruiqing LuState Key Laboratory of Chemical Oncogenomics, and the Institute of Biopharmaceutical and Health Engineering (iBHE), Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Yankai DongState Key Laboratory of Chemical Oncogenomics, and the Institute of Biopharmaceutical and Health Engineering (iBHE), Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Xiaosong LiState Key Laboratory of Chemical Oncogenomics, and the Institute of Biopharmaceutical and Health Engineering (iBHE), Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Jundong XieState Key Laboratory of Chemical Oncogenomics, and the Institute of Biopharmaceutical and Health Engineering (iBHE), Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Ren-He XuFaculty of Health Sciences, University of Macau, Taipa, China.
Haidong JiaShanghai Jahwa United Co., Ltd, Shanghai, China.
Yan KangShanghai Jahwa United Co., Ltd, Shanghai, China.
Yaojiong WuTsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China.
Shenzhen University Health Science Center · CNTsinghua–Berkeley Shenzhen Institute · CNDanaher (China) · CNUniversity of Chinese Academy of Sciences · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin harbours transcriptionally and functionally heterogeneous mesenchymal cells that participate in various physiological activities by secreting biochemical cues. In this study, we aimed to identify a new subpopulation of dermal mesenchymal cells that enhance hair follicle regeneration through a paracrine mechanism. Integrated single-cell RNA sequencing (scRNA-seq) data analysis revealed epidermal growth factor receptor (EGFR) as a marker of distinct fibroblast subpopulation in the neonatal murine dermis. Immunofluorescence staining and fluorescence-activated cell sorting (FACS) were used to validate the existence of the cell population in Krt14-rtTA-H2BGFP mouse. The difference of gene expression between separated cell subpopulation was examined by real-time PCR. Potential effect of the designated factor on hair follicle regeneration was observed after the application on excisional wounds in Krt14-rtTA-H2BGFP mouse. Immunofluorescence staining demonstrated the existence of dermal EGFR

Indexed as

DermisHair FollicleAnimalsErbB ReceptorsInsulin-Like Growth Factor IMiceSkinEGFR protein, mouseErbB Receptorsinsulin-like growth factor-1, mouseInsulin-Like Growth Factor Icell subpopulationEGFRhair follicle regenerationIgf1scRNA-seq

Identifiers

PMID37165726
PMCPMC10273066
OpenAlexW4376131342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.