Evidence map›Paper›PMID 37165609›Full record

ArticlePsychiatry and clinical neurosciences2023

Parental history of dementia and the risk of dementia: A cross-sectional analysis of a global collaborative study.

Dae Jong Oh, Jong Bin Bae, Darren M Lipnicki, Ji Won Han, Perminder S Sachdev, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim and 34 more

Open access · bronzeAbstract read
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Article in Psychiatry and clinical neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 11 countries.

Dae Jong OhWorkplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Jong Bin BaeDepartment of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
Darren M LipnickiCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Ji Won HanDepartment of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
Perminder S SachdevCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9595-3220
Tae Hui KimDepartment of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea.
Kyung Phil KwakDepartment of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea.
Bong Jo KimDepartment of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea.
Shin Gyeom KimDepartment of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
Jeong Lan KimDepartment of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea.
Seok Woo MoonDepartment of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea.
Joon Hyuk ParkDepartment of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea.
Seung-Ho RyuDepartment of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea.
Jong Chul YounDepartment of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, South Korea.
Dong Young LeeDepartment of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.ORCID https://orcid.org/0000-0001-8976-8320
Dong Woo LeeDepartment of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
Seok Bum LeeDepartment of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
Jung Jae LeeDepartment of Psychiatry, Dankook University Hospital, Cheonan, South Korea.
Jin Hyeong JhooDepartment of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea.
Ingmar SkoogDepartment of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), University of Gothenburg, Mölndal, Sweden.
Jenna NajarDepartment of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), University of Gothenburg, Mölndal, Sweden.
Therese R SternerDepartment of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), University of Gothenburg, Mölndal, Sweden.
Antonio GuaitaGolgi Cenci Foundation, Abbiategrasso, Italy.
Roberta VaccaroGolgi Cenci Foundation, Abbiategrasso, Italy.
Elena RolandiGolgi Cenci Foundation, Abbiategrasso, Italy.
Nikolaos ScarmeasDepartment of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.ORCID https://orcid.org/0000-0003-2171-7337
Mary H KosmidisLab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Susanne RoehrInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany.
Jacqueline DominguezInstitute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines.
Ma Fe De GuzmanInstitute for Dementia Care Asia, Quezon City, Philippines.
Krizelle Cleo FowlerInstitute for Dementia Care Asia, Quezon City, Philippines.
Antonio LoboDepartment of Medicine and Psychiatry, Zaragoza University, Aragon, Spain.
Pedro SazDepartment of Medicine and Psychiatry, Zaragoza University, Aragon, Spain.
Raul Lopez-AntonDepartamento de Psicología y Sociología, Universidad de Zaragoza, Aragon, Spain.
Kaarin J AnsteySchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Nicolas CherbuinCentre for Mental Health Research, Australian National University, Canberra, Canberra, Australia.
Moyra E MortbySchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Julian TrollorCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Nicole KochanCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
Ki Woong KimDepartment of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.ORCID https://orcid.org/0000-0002-1103-3858
for Cohort Studies of Memory in an International Consortium (COSMIC)
UNSW Sydney · AUSeoul National University · KRFondazione Golgi Cenci · ITUniversidad de Zaragoza · ESAustralian National University · AUDankook University Hospital · KRPartnerships in Environmental Management for the Seas of East Asia · PHSahlgrenska University Hospital · SEAristotle University of Thessaloniki · GRChungnam National University · KRGyeongju University · KRGyeongsang National University · KRHarokopio University of Athens · GRJeju National University Hospital · KRKangbuk Samsung Hospital · KRKangwon National University Hospital · KRKonkuk University · KRKonkuk University Medical Center · KRLeipzig University · DENational and Kapodistrian University of Athens · GR

Funding

A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC CollaborationR01AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI Perminder S SACHDEV · 2023 to 2026
$5.9M
COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
Alzheimer's Association IIRG-09133014NIA NIH HHS R01 AG057531NIA NIH HHS RF1 AG057531NIA NIH HHS RF1AG057531Wellcome TrustWellcome Trust GR066133Wellcome Trust GR08002
6 · The paper itself

Abstract

backgroundParental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring.

methodsFor this cross-sectional study, we harmonized and pooled data for 17,194 older adults from nine population-based cohorts of eight countries. These studies conducted face-to-face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring.

resultsThe mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15-1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31-2.26), but not with the risk of non-AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15-1.97) and AD (OR = 1.80, 95% CI = 1.33-2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28-3.55 in males; OR = 1.68, 95% CI = 1.16-2.44 for females).

conclusionsMaternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials.

Indexed as

Alzheimer DiseaseAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedParentsAlzheimer's diseasedementiamaternal historyparental historysex

Identifiers

PMID37165609
PMCPMC10524874
OpenAlexW4376132693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.