Evidence map›Paper›PMID 37165603›Full record

ArticleScandinavian journal of public health2023

Does misclassification of former tobacco smokers explain the 'smoker's paradox' in the risk of COVID-19? Insights from the Stockholm Public Health Cohort.

Ahmed N Shaaban, Filip Andersson, Cecilia Magnusson, Nicola Orsini, Ida H Caspersen, Sebastian Peña, Sakari Karvonen, Per Magnus, Maria R Galanti

Open access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ahmed N ShaabanDepartment of Global Public Health, Karolinska Institutet, Sweden.ORCID 0000-0001-8483-638X
Filip AnderssonDepartment of Global Public Health, Karolinska Institutet, Sweden.
Cecilia MagnussonDepartment of Global Public Health, Karolinska Institutet, Sweden.
Nicola OrsiniDepartment of Global Public Health, Karolinska Institutet, Sweden.
Ida H CaspersenCentre for Fertility and Health, Norwegian Institute of Public Health, Norway.
Sebastian PeñaFinnish Institute for Health and Welfare, Finland.
Sakari KarvonenFinnish Institute for Health and Welfare, Finland.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Norway.
Maria R GalantiDepartment of Global Public Health, Karolinska Institutet, Sweden.ORCID 0000-0002-7805-280X
Karolinska Institutet · SEFinnish Institute for Health and Welfare · FINorwegian Institute of Public Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between tobacco smoking and the risk of COVID-19 and its adverse outcomes is controversial, as studies reported contrasting findings. Bias due to misclassification of the exposure in the analyses of current versus non-current smoking could be a possible explanation because former smokers may have higher background risks of the disease due to co-morbidity. The aim of the study was to investigate the extent of this potential bias by separating non-, former, and current smokers when assessing the risk or prognosis of diseases.

methodsWe analysed data from 43,400 participants in the Stockholm Public Health Cohort, Sweden, with information on smoking obtained prior to the pandemic. We estimated the risk of COVID-19, hospital admissions and death for (a) former and current smokers relative to non-smokers, (b) current smokers relative to non-current smokers, that is, including former smokers; adjusting for potential confounders (aRR).

resultsThe aRR of a COVID-19 diagnosis was elevated for former smokers compared with non-smokers (1.07; 95% confidence interval (CI) =1.00-1.15); including hospital admission with any COVID-19 diagnosis (aRR= 1.23; 95% CI = 1.03-1.48); or with COVID-19 as the main diagnosis (aRR=1.23, 95% CI= 1.01-1.49); and death within 30 days with COVID-19 as the main or a contributory cause (aRR=1.40; 95% CI=1.00-1.95). Current smoking was negatively associated with risk of COVID-19 (aRR=0.79; 95% CI=0.68-0.91).

conclusions

Indexed as

COVID-19SmokersCOVID-19 TestingHumansPublic HealthCOVID-19former smokersmisclassification biaspopulation-based cohortSARS-CoV-2Swedentobacco smoking

Identifiers

PMID37165603
PMCPMC10183343
OpenAlexW4376132453

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.