Evidence map›Paper›PMID 37165504›Full record

SynthesisCurrent medicinal chemistry2024

Blood-based microRNAs as Potential Diagnostic Biomarkers for Melanoma: A Meta-Analysis.

AmirHossein Aalami, Hossein Abdeahad, Ali Mokhtari, Farnoosh Aalami, Amir Amirabadi, Ehsan Kargar Aliabadi, Omid Pirzade, Amirhossein Sahebkar

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

AmirHossein AalamiDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Hossein AbdeahadDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Ali MokhtariDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Farnoosh AalamiStudent Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Amir AmirabadiDepartment of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.
Ehsan Kargar AliabadiBiochemical Research Center, Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Omid PirzadeDepartment of English Language and Literature, Faculty of Literature and Humanities, Hakim Sabzevari University, Sabzevar, Iran.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCirculating microRNAs (miRNAs) serve as noninvasive diagnostic markers in many cancers. This meta-analysis aims to evaluate the diagnostic efficacy of circulating microRNAs for melanoma. MATERIALS AND

methodsThe pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and ROC curve were evaluated using the Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software packages. To investigate the heterogeneity, the I

resultsA total of 9 articles covering 13 studies (more than 50 miRs individually and in combination) were included, containing 1,355 participants (878 cases and 477 controls). The overall pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR), and AUC were 0.78 (95% CI: 0.76-0.81), 0.80 (95% CI: 0.77-0.83), 4.32 (95% CI: 3.21-5.82), 0.17 (95% CI: 0.09-0.32), 28.0 (95% CI: 15.34-51.09), and 0.91, respectively. According to Begg's and Egger's tests, there was no publication bias (Begg's p = 0.160 and Egger's p = 0.289).

conclusionCirculating miRNAs can serve as fair and non-invasive diagnostic biomarkers for melanoma. Additionally, specific miRNAs still need to be discovered for diagnosing melanoma.

Indexed as

Biomarkers, TumorMelanomaCirculating MicroRNAHumansBiomarkers, TumorCirculating MicroRNAbiomarkercirculating miRNAsdiagnosticMalignant melanomameta-analysis.ROC curveskin cancer

Identifiers

PMID37165504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.