Evidence map›Paper›PMID 37165488›Full record

ArticleCurrent computer-aided drug design2024

Synthesis, Molecular Modeling and Biological Evaluation of Novel Trifluoromethyl Benzamides as Promising CETP Inhibitors.

Reema Abu Khalaf, Amani Abusaad, Bara'a Al-Nawaiseh, Dima Sabbah, Ghadeer Albadawi

Abstract read
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In one paragraph

Article in Current computer-aided drug design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Reema Abu KhalafDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Amani AbusaadDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Bara'a Al-NawaisehDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Dima SabbahDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Ghadeer AlbadawiDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Al-Zaytoonah University of Jordan · JO

Funding

Deanship of Scientific Research and Innovation at Al-Zaytoonah University of Jordan Grant Number: 12/08/2021-2022
6 · The paper itself

Abstract

backgroundHyperlipidemia is considered a major risk factor for the progress of atherosclerosis.

objectiveCholesteryl ester transfer protein (CETP) facilitates the relocation of cholesterol esters from HDL to LDL. CETP inhibition produces higher HDL and lower LDL levels.

methodsSynthesis of nine benzylamino benzamides 8a-8f and 9a-9c was performed.

results

conclusionPharmacophore mapping showed that this scaffold endorsed CETP inhibitors features and consequently elaborated the high CETP binding affinity.

Indexed as

BenzamidesCholesterol Ester Transfer ProteinsModels, MolecularMolecular Docking SimulationAnticholesteremic AgentsHumansStructure-Activity RelationshipAnticholesteremic AgentsBenzamidesCETP protein, humanCholesterol Ester Transfer ProteinsCETP inhibitorshyperlipidemiainduced-fit dockingmolecular docking.pharmacophore mappingtrifluoromethyl benzamides

Identifiers

PMID37165488
OpenAlexW4376133546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.