Evidence map›Paper›PMID 37165388›Full record

ArticleBMC complementary medicine and therapies2023

Bactericidal and anti-inflammatory effects of Moquilea tomentosa Benth. flavonoid-rich leaf extract.

Mariana Freire Campos, Leopoldo Clemente Baratto, Vinícius Mendes Vidal, Ivana Ventura Nascimento, Brendo Araujo Gomes, Genes de Lima Martins Neto, Priscilla Christina Olsen, Rodrigo Ribeiro Tarjano Leo, Lilian Oliveira Moreira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mariana Freire CamposLaboratório de Anatomia Vegetal, Departamento de Botânica, Federal University of the State of Rio de Janeiro (UNRIO), Rio de Janeiro, Brazil.
Leopoldo Clemente BarattoLaboratório de Farmacognosia Aplicada, Departamento de Produtos Naturais e Alimentos, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Vinícius Mendes VidalLaboratório de Bacteriologia e Imunologia Clínica (LABIC), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Ivana Ventura NascimentoLaboratório de Bacteriologia e Imunologia Clínica (LABIC), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Brendo Araujo GomesLaboratório de Anatomia Vegetal, Departamento de Botânica, Federal University of the State of Rio de Janeiro (UNRIO), Rio de Janeiro, Brazil.
Genes de Lima Martins NetoLaboratório de Anatomia Vegetal, Departamento de Botânica, Federal University of the State of Rio de Janeiro (UNRIO), Rio de Janeiro, Brazil.
Priscilla Christina OlsenLaboratório de Bacteriologia e Imunologia Clínica (LABIC), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Rodrigo Ribeiro Tarjano LeoLaboratório de Anatomia Vegetal, Departamento de Botânica, Federal University of the State of Rio de Janeiro (UNRIO), Rio de Janeiro, Brazil.
Lilian Oliveira MoreiraLaboratório de Bacteriologia e Imunologia Clínica (LABIC), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. lilian@pharma.ufrj.br.
Universidade Federal do Estado do Rio de Janeiro · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNatural products are an important source of bioproducts with pharmacological properties. Here we investigate the components of leaves from M. tomentosa Benth. (Fritsch) (Chrysobalanaceae) and its effects on bacterial cell growth, biofilm production and macrophage activity.

methodsThe effect of the different leaf extracts against bacterial cell growth was performed using the microdilution method. The most active extract was analyzed by mass spectrometry, and its effect on bacterial biofilm production was evaluated on polystyrene plates. The extract effect on macrophage activity was tested in the RAW264.7 cell line, which was stimulated with different concentrations of the extract in the presence or absence of LPS.

resultsWe show that the ethyl acetate (EtOAc) extract was the most effective against bacterial cell growth. EtOAc extract DI-ESI (-)MS

conclusionM. tomentosa flavonoid-enriched EtOAc extract presented a bactericidal and anti-inflammatory pharmacological potential.

Indexed as

ChrysobalanaceaeFlavonoidsAnti-Bacterial AgentsAnti-Inflammatory AgentsBacteriaLipopolysaccharidesPlant ExtractsStaphylococcus aureusAnti-Bacterial AgentsAnti-Inflammatory AgentsFlavonoidsLipopolysaccharidesPlant ExtractsAntibacterial activityBiofilmCytokinesFlavonoid-O-glycosidesMass spectrometryNatural products

Identifiers

PMID37165388
PMCPMC10173630
OpenAlexW4376133671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.